A cross-sectional analysis of the relationship between the non-high density to high density lipoprotein cholesterol ratio (NHHR) and kidney stone risk in American adults

Bibliographic Details
Title: A cross-sectional analysis of the relationship between the non-high density to high density lipoprotein cholesterol ratio (NHHR) and kidney stone risk in American adults
Authors: Yuan-Zhuo Du, Qian-Xi Dong, Hong-Ji Hu, Biao Guo, Yi-He Li, Ji Zhang, Fu-Chun Li, Ju Guo
Source: Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-10 (2024)
Publisher Information: BMC, 2024.
Publication Year: 2024
Collection: LCC:Nutritional diseases. Deficiency diseases
Subject Terms: NHHR, Kidney stones, NHANES, Cross-sectional study, Nutritional diseases. Deficiency diseases, RC620-627
More Details: Abstract Background Recent interest in the Non-High Density to High Density Lipoprotein Cholesterol ratio (NHHR) has emerged due to its potential role in metabolic disorders. However, the connection between NHHR and the development of kidney stones still lacks clarity. The primary goal of this research is to explore how NHHR correlates with kidney stone incidence. Methods An analysis was conducted on the data collected by the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018, focusing on adults over 20 years diagnosed with kidney stones and those with available NHHR values. Employing weighted logistic regression and Restricted Cubic Spline (RCS) models, NHHR levels’ correlation with kidney stone risk was examined. Extensive subgroup analyses were conducted for enhanced reliability of the findings. Results The findings indicate a heightened kidney stone risk for those at the highest NHHR levels relative to those at the lowest (reference group). A notable non-linear correlation of NHHR with kidney stone incidence has been observed, with a significant P-value (
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1476-511X
Relation: https://doaj.org/toc/1476-511X
DOI: 10.1186/s12944-024-02150-9
Access URL: https://doaj.org/article/17bb135ce828438f88de6617c195f86a
Accession Number: edsdoj.17bb135ce828438f88de6617c195f86a
Database: Directory of Open Access Journals
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More Details
ISSN:1476511X
DOI:10.1186/s12944-024-02150-9
Published in:Lipids in Health and Disease
Language:English