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Evolution and Clinical Advances of Platelet-Rich Fibrin in Musculoskeletal Regeneration

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Title: Evolution and Clinical Advances of Platelet-Rich Fibrin in Musculoskeletal Regeneration
Authors: Ragunanthan Narayanaswamy, Bishnu Prasad Patro, Naveen Jeyaraman, Prakash Gangadaran, Ramya Lakshmi Rajendran, Arulkumar Nallakumarasamy, Madhan Jeyaraman, Prasanna Ramani, Byeong-Cheol Ahn
Source: Bioengineering, Vol 10, Iss 1, p 58 (2023)
Publisher Information: MDPI AG, 2023.
Publication Year: 2023
Collection: LCC:Technology
LCC:Biology (General)
Subject Terms: platelet-rich fibrin, cytokines, intercellular signaling, growth factors, Technology, Biology (General), QH301-705.5
More Details: Over the past few decades, various forms of platelet concentrates have evolved with significant clinical utility. The newer generation products, including leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF), have shown superior biological properties in musculoskeletal regeneration than the first-generation concentrates, such as platelet-rich plasma (PRP) and plasma rich in growth factors. These newer platelet concentrates have a complete matrix of physiological fibrin that acts as a scaffold with a three-dimensional (3D) architecture. Further, it facilitates intercellular signaling and migration, thereby promoting angiogenic, chondrogenic, and osteogenic activities. A-PRF with higher leukocyte inclusion possesses antimicrobial activity than the first generations. Due to the presence of enormous amounts of growth factors and anti-inflammatory cytokines that are released, A-PRF has the potential to replicate the various physiological and immunological factors of wound healing. In addition, there are more neutrophils, monocytes, and macrophages, all of which secrete essential chemotactic molecules. As a result, both L-PRF and A-PRF are used in the management of musculoskeletal conditions, such as chondral injuries, tendinopathies, tissue regeneration, and other sports-related injuries. In addition to this, its applications have been expanded to include the fields of reconstructive cosmetic surgery, wound healing in diabetic patients, and maxillofacial surgeries.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2306-5354
Relation: https://www.mdpi.com/2306-5354/10/1/58; https://doaj.org/toc/2306-5354
DOI: 10.3390/bioengineering10010058
Access URL: https://doaj.org/article/c17b24ba0aa8425a8e1af12604a3da9b
Accession Number: edsdoj.17b24ba0aa8425a8e1af12604a3da9b
Database: Directory of Open Access Journals
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  Data: <searchLink fieldCode="AR" term="%22Ragunanthan+Narayanaswamy%22">Ragunanthan Narayanaswamy</searchLink><br /><searchLink fieldCode="AR" term="%22Bishnu+Prasad+Patro%22">Bishnu Prasad Patro</searchLink><br /><searchLink fieldCode="AR" term="%22Naveen+Jeyaraman%22">Naveen Jeyaraman</searchLink><br /><searchLink fieldCode="AR" term="%22Prakash+Gangadaran%22">Prakash Gangadaran</searchLink><br /><searchLink fieldCode="AR" term="%22Ramya+Lakshmi+Rajendran%22">Ramya Lakshmi Rajendran</searchLink><br /><searchLink fieldCode="AR" term="%22Arulkumar+Nallakumarasamy%22">Arulkumar Nallakumarasamy</searchLink><br /><searchLink fieldCode="AR" term="%22Madhan+Jeyaraman%22">Madhan Jeyaraman</searchLink><br /><searchLink fieldCode="AR" term="%22Prasanna+Ramani%22">Prasanna Ramani</searchLink><br /><searchLink fieldCode="AR" term="%22Byeong-Cheol+Ahn%22">Byeong-Cheol Ahn</searchLink>
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  Data: Bioengineering, Vol 10, Iss 1, p 58 (2023)
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  Data: MDPI AG, 2023.
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  Data: <searchLink fieldCode="DE" term="%22platelet-rich+fibrin%22">platelet-rich fibrin</searchLink><br /><searchLink fieldCode="DE" term="%22cytokines%22">cytokines</searchLink><br /><searchLink fieldCode="DE" term="%22intercellular+signaling%22">intercellular signaling</searchLink><br /><searchLink fieldCode="DE" term="%22growth+factors%22">growth factors</searchLink><br /><searchLink fieldCode="DE" term="%22Technology%22">Technology</searchLink><br /><searchLink fieldCode="DE" term="%22Biology+%28General%29%22">Biology (General)</searchLink><br /><searchLink fieldCode="DE" term="%22QH301-705%2E5%22">QH301-705.5</searchLink>
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  Data: Over the past few decades, various forms of platelet concentrates have evolved with significant clinical utility. The newer generation products, including leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF), have shown superior biological properties in musculoskeletal regeneration than the first-generation concentrates, such as platelet-rich plasma (PRP) and plasma rich in growth factors. These newer platelet concentrates have a complete matrix of physiological fibrin that acts as a scaffold with a three-dimensional (3D) architecture. Further, it facilitates intercellular signaling and migration, thereby promoting angiogenic, chondrogenic, and osteogenic activities. A-PRF with higher leukocyte inclusion possesses antimicrobial activity than the first generations. Due to the presence of enormous amounts of growth factors and anti-inflammatory cytokines that are released, A-PRF has the potential to replicate the various physiological and immunological factors of wound healing. In addition, there are more neutrophils, monocytes, and macrophages, all of which secrete essential chemotactic molecules. As a result, both L-PRF and A-PRF are used in the management of musculoskeletal conditions, such as chondral injuries, tendinopathies, tissue regeneration, and other sports-related injuries. In addition to this, its applications have been expanded to include the fields of reconstructive cosmetic surgery, wound healing in diabetic patients, and maxillofacial surgeries.
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