Bibliographic Details
| Title: |
Association between non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio and macroalbuminuria: evidence from NHANES 1999-2018 |
| Authors: |
Dongli Huang, Yuan He |
| Source: |
Frontiers in Endocrinology, Vol 16 (2025) |
| Publisher Information: |
Frontiers Media S.A., 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio, macroalbuminuria, NHANES, cross-sectional study, ACR - albumin to creatinine ratio, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
PurposeThe non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a crucial lipid marker associated with various cardiovascular diseases. However, its relationship with kidney injury, particularly albuminuria, remains poorly understood. This study aims to investigate the association between NHHR and macroalbuminuria in U.S. adultsPatients and methodsThis cross-sectional study utilized data from the 1999–2018 National Health and Nutrition Examination Survey (NHANES). NHHR was calculated as (Total cholesterol - HDL cholesterol)/HDL cholesterol. Macroalbuminuria was defined by an albumin-creatinine ratio (ACR) >300 mg/g. Logistic regression, smoothed curve fitting, subgroup analyses, and sensitivity analysis were employed to assess the relationship between NHHR and macroalbuminuria.ResultsA total of 41,225 participants were included in the analysis. Higher NHHR was significantly associated with an increased likelihood of macroalbuminuria (OR = 1.34, 95% CI: 1.13–1.59, p=0.0007). Subgroup analysis revealed a stronger association in participants with BMI ≥30 kg/m2(OR = 1.89, 95% CI: 1.44–2.47, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2392 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fendo.2025.1503780/full; https://doaj.org/toc/1664-2392 |
| DOI: |
10.3389/fendo.2025.1503780 |
| Access URL: |
https://doaj.org/article/e17686276b134d18bb84ba8d5dabc884 |
| Accession Number: |
edsdoj.17686276b134d18bb84ba8d5dabc884 |
| Database: |
Directory of Open Access Journals |
