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Evaluating clinical importance of sensitization to Ara h 6 quantitively in Japanese children

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Title: Evaluating clinical importance of sensitization to Ara h 6 quantitively in Japanese children
Authors: Sakura Sato, MD, Noriyuki Yanagida, MD, PhD, Ken-ichi Nagakura, MD, PhD, Kyohei Takahashi, MD, PhD, MPH, Magnus P. Borres, MD, PhD, Motohiro Ebisawa, MD, PhD
Source: World Allergy Organization Journal, Vol 17, Iss 12, Pp 101001- (2024)
Publisher Information: Elsevier, 2024.
Publication Year: 2024
Collection: LCC:Immunologic diseases. Allergy
Subject Terms: Anaphylaxis, Ara h 6, Component-resolved diagnostics, Food allergy, Peanut, Immunologic diseases. Allergy, RC581-607
More Details: Background: The clinical importance of sensitization to Arachis hypogaea 6 (Ara h 6) in Japanese children remains unelucidated. We aimed to quantitatively evaluate the clinical importance of sensitization to Ara h 6 in managing peanut allergy in Japanese children. Methods: We retrospectively analyzed the data of children with or without symptoms induced by an oral food challenge or home dosing of up to 3 g of peanuts. The specific immunoglobulin E (sIgE) levels against peanuts, Ara h 2, and Ara h 6 were quantified using an ImmunoCAP assay. Results: We examined 273 patients aged 4.6–9.8 years (median 6.3); 189 (69%) were male, 187 (68%) had allergies to peanuts, and 43 (16%) had anaphylactic reactions to peanuts. Ara h 6 and Ara h 2 co-sensitization was observed in 224 patients (82%). Ara h 6-sIgE levels were significantly associated with the probability of allergic reactions and anaphylaxis. The 95% probability of allergic reactions to peanuts was obtained at 44.5 kUA/L of Ara h 6-sIgE, but the 95% probability of anaphylaxis could not be calculated. A combination of Ara h 6 and Ara h 2 could not improve diagnostic accuracy for allergic reactions and anaphylaxis to peanuts. Conclusion: Sensitization to Ara h 6 played an important role in managing peanut allergy in Japanese children, and sIgE levels provided valuable predictive information for allergic reactions to peanuts. However, the measurement of Ara h 6 did not improve the diagnostic accuracy of anaphylaxis, and Ara h 2 alone might be sufficient for clinical evaluation in peanut allergy.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1939-4551
Relation: http://www.sciencedirect.com/science/article/pii/S1939455124001339; https://doaj.org/toc/1939-4551
DOI: 10.1016/j.waojou.2024.101001
Access URL: https://doaj.org/article/1726ffe74d1f49ec9d952de9c592a713
Accession Number: edsdoj.1726ffe74d1f49ec9d952de9c592a713
Database: Directory of Open Access Journals
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  Data: <searchLink fieldCode="AR" term="%22Sakura+Sato%2C+MD%22">Sakura Sato, MD</searchLink><br /><searchLink fieldCode="AR" term="%22Noriyuki+Yanagida%2C+MD%2C+PhD%22">Noriyuki Yanagida, MD, PhD</searchLink><br /><searchLink fieldCode="AR" term="%22Ken-ichi+Nagakura%2C+MD%2C+PhD%22">Ken-ichi Nagakura, MD, PhD</searchLink><br /><searchLink fieldCode="AR" term="%22Kyohei+Takahashi%2C+MD%2C+PhD%2C+MPH%22">Kyohei Takahashi, MD, PhD, MPH</searchLink><br /><searchLink fieldCode="AR" term="%22Magnus+P%2E+Borres%2C+MD%2C+PhD%22">Magnus P. Borres, MD, PhD</searchLink><br /><searchLink fieldCode="AR" term="%22Motohiro+Ebisawa%2C+MD%2C+PhD%22">Motohiro Ebisawa, MD, PhD</searchLink>
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  Data: World Allergy Organization Journal, Vol 17, Iss 12, Pp 101001- (2024)
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  Data: Elsevier, 2024.
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  Data: 2024
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  Data: <searchLink fieldCode="DE" term="%22Anaphylaxis%22">Anaphylaxis</searchLink><br /><searchLink fieldCode="DE" term="%22Ara+h+6%22">Ara h 6</searchLink><br /><searchLink fieldCode="DE" term="%22Component-resolved+diagnostics%22">Component-resolved diagnostics</searchLink><br /><searchLink fieldCode="DE" term="%22Food+allergy%22">Food allergy</searchLink><br /><searchLink fieldCode="DE" term="%22Peanut%22">Peanut</searchLink><br /><searchLink fieldCode="DE" term="%22Immunologic+diseases%2E+Allergy%22">Immunologic diseases. Allergy</searchLink><br /><searchLink fieldCode="DE" term="%22RC581-607%22">RC581-607</searchLink>
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  Label: Description
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  Data: Background: The clinical importance of sensitization to Arachis hypogaea 6 (Ara h 6) in Japanese children remains unelucidated. We aimed to quantitatively evaluate the clinical importance of sensitization to Ara h 6 in managing peanut allergy in Japanese children. Methods: We retrospectively analyzed the data of children with or without symptoms induced by an oral food challenge or home dosing of up to 3 g of peanuts. The specific immunoglobulin E (sIgE) levels against peanuts, Ara h 2, and Ara h 6 were quantified using an ImmunoCAP assay. Results: We examined 273 patients aged 4.6–9.8 years (median 6.3); 189 (69%) were male, 187 (68%) had allergies to peanuts, and 43 (16%) had anaphylactic reactions to peanuts. Ara h 6 and Ara h 2 co-sensitization was observed in 224 patients (82%). Ara h 6-sIgE levels were significantly associated with the probability of allergic reactions and anaphylaxis. The 95% probability of allergic reactions to peanuts was obtained at 44.5 kUA/L of Ara h 6-sIgE, but the 95% probability of anaphylaxis could not be calculated. A combination of Ara h 6 and Ara h 2 could not improve diagnostic accuracy for allergic reactions and anaphylaxis to peanuts. Conclusion: Sensitization to Ara h 6 played an important role in managing peanut allergy in Japanese children, and sIgE levels provided valuable predictive information for allergic reactions to peanuts. However, the measurement of Ara h 6 did not improve the diagnostic accuracy of anaphylaxis, and Ara h 2 alone might be sufficient for clinical evaluation in peanut allergy.
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