Bibliographic Details
| Title: |
Evaluating clinical importance of sensitization to Ara h 6 quantitively in Japanese children |
| Authors: |
Sakura Sato, MD, Noriyuki Yanagida, MD, PhD, Ken-ichi Nagakura, MD, PhD, Kyohei Takahashi, MD, PhD, MPH, Magnus P. Borres, MD, PhD, Motohiro Ebisawa, MD, PhD |
| Source: |
World Allergy Organization Journal, Vol 17, Iss 12, Pp 101001- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
Anaphylaxis, Ara h 6, Component-resolved diagnostics, Food allergy, Peanut, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Background: The clinical importance of sensitization to Arachis hypogaea 6 (Ara h 6) in Japanese children remains unelucidated. We aimed to quantitatively evaluate the clinical importance of sensitization to Ara h 6 in managing peanut allergy in Japanese children. Methods: We retrospectively analyzed the data of children with or without symptoms induced by an oral food challenge or home dosing of up to 3 g of peanuts. The specific immunoglobulin E (sIgE) levels against peanuts, Ara h 2, and Ara h 6 were quantified using an ImmunoCAP assay. Results: We examined 273 patients aged 4.6–9.8 years (median 6.3); 189 (69%) were male, 187 (68%) had allergies to peanuts, and 43 (16%) had anaphylactic reactions to peanuts. Ara h 6 and Ara h 2 co-sensitization was observed in 224 patients (82%). Ara h 6-sIgE levels were significantly associated with the probability of allergic reactions and anaphylaxis. The 95% probability of allergic reactions to peanuts was obtained at 44.5 kUA/L of Ara h 6-sIgE, but the 95% probability of anaphylaxis could not be calculated. A combination of Ara h 6 and Ara h 2 could not improve diagnostic accuracy for allergic reactions and anaphylaxis to peanuts. Conclusion: Sensitization to Ara h 6 played an important role in managing peanut allergy in Japanese children, and sIgE levels provided valuable predictive information for allergic reactions to peanuts. However, the measurement of Ara h 6 did not improve the diagnostic accuracy of anaphylaxis, and Ara h 2 alone might be sufficient for clinical evaluation in peanut allergy. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1939-4551 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1939455124001339; https://doaj.org/toc/1939-4551 |
| DOI: |
10.1016/j.waojou.2024.101001 |
| Access URL: |
https://doaj.org/article/1726ffe74d1f49ec9d952de9c592a713 |
| Accession Number: |
edsdoj.1726ffe74d1f49ec9d952de9c592a713 |
| Database: |
Directory of Open Access Journals |
