Analysis of changes in high‐mobility group box 1, receptor for advanced glycation endproducts, and T helper 17/regulatory T balance in severe preeclampsia with acute heart failure
| Title: | Analysis of changes in high‐mobility group box 1, receptor for advanced glycation endproducts, and T helper 17/regulatory T balance in severe preeclampsia with acute heart failure |
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| Authors: | Chen De, Liang Xuan, Zhang jingjing, Zhang Honghong, Zuo Kun, Du Song, Song Yaqi, Jiang Ying, Cheng Cheng, Liu Jian |
| Source: | The Journal of Clinical Hypertension, Vol 26, Iss 4, Pp 431-440 (2024) |
| Publisher Information: | Wiley, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: | acute heart failure, high‐mobility group box 1 protein, receptor for advanced glycation endproducts, severe preeclampsia, Th17/Treg, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: | Abstract We measured the levels of High‐Mobility Group Box 1 (HMGB1), Receptor for Advanced Glycation Endproducts (RAGE), T Helper 17 cells (Th17), Regulatory T cells (Treg), and related cytokines in the peripheral blood of patients with severe preeclampsia (SPE) complicated with acute heart failure (AHF) to explore the expression changes in these indicators. In total, 96 patients with SPE admitted to Gansu Provincial Maternity and Child‐care Hospital between June 2020 and June 2022 were included in the study. The patients were divided into SPE+AHF (40 patients) and SPE (56 patients) groups based on whether they suffered from AHF. Additionally, 56 healthy pregnant women who either received prenatal examinations or were admitted to our hospital for delivery during the same period were selected as the healthy control group. An enzyme‐linked immunosorbent assay was performed to detect the expression levels of HMGB1, RAGE, interleukin (IL)‐17, IL‐6, transforming growth factor β (TGF‐β), IL‐10, and NT‐proBNP in plasma. Flow cytometry was employed to determine the percentages of Th17 and Treg cells. Compared to the healthy control group, the SPE+AHF and SPE groups had higher plasma levels of HMGB1 and RAGE expression, higher Th17 percentage and Th17/Treg ratio, and lower Treg percentage. Compared to the SPE group, the SPE+AHF group had higher plasma levels of HMGB1 and RAGE expression, higher Th17 percentage and Th17/Treg ratio, and lower Treg percentage (P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1751-7176 1524-6175 |
| Relation: | https://doaj.org/toc/1524-6175; https://doaj.org/toc/1751-7176 |
| DOI: | 10.1111/jch.14784 |
| Access URL: | https://doaj.org/article/16fb42e0814a4430b6af76b6223ec68b |
| Accession Number: | edsdoj.16fb42e0814a4430b6af76b6223ec68b |
| Database: | Directory of Open Access Journals |
| ISSN: | 17517176 15246175 |
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| DOI: | 10.1111/jch.14784 |
| Published in: | The Journal of Clinical Hypertension |
| Language: | English |