Bibliographic Details
| Title: |
Case Report: A Case of Severe Clinical Deterioration in a Patient With Multiple Sclerosis |
| Authors: |
Katharina Breitkopf, Aykut Aytulun, Moritz Förster, Bastian Kraus, Bernd Turowski, Doreen Huppert, Norbert Goebels, Harald Hefter, Orhan Aktas, Imke Metz, Wolfgang Brück, Guido Reifenberger, Hans-Peter Hartung, Philipp Albrecht |
| Source: |
Frontiers in Neurology, Vol 11 (2020) |
| Publisher Information: |
Frontiers Media S.A., 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Neurology. Diseases of the nervous system |
| Subject Terms: |
multiple sclerosis, tumefactive multiple sclerosis, demyelinating disease, multiple sclerosis rebound, immunocompromised multiple sclerosis patient, progressive brain lesions, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: |
Tumefactive multiple sclerosis (MS) is a rare variant of MS that may lead to a rapidly progressive clinical deterioration requiring a multidisciplinary diagnostic workup. Our report describes the diagnostic and therapeutic approach of a rare and extremely severe course of MS. A 51-year-old man with an 8-year history of relapsing-remitting MS (RRMS) was admitted with a subacute progressive left lower limb weakness and deterioration of walking ability. After extensive investigations including repeated MRI, microbiological, serological, cerebrospinal fluid (CSF) studies, and finally brain biopsy, the diagnosis of a tumefactive MS lesion was confirmed. Despite repeated intravenous (IV) steroids as well as plasma exchanges and IV foscarnet and ganciclovir owing to low copy numbers of human herpesvirus 6 (HHV-6) DNA in polymerase chain reaction (PCR) analysis, the patient did not recover. The clinical presentation of tumefactive MS is rare and variable. Brain biopsy for histopathological workup should be considered in immunocompromised patients with rapidly progressive clinical deterioration with brain lesions of uncertain cause. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2295 |
| Relation: |
https://www.frontiersin.org/article/10.3389/fneur.2020.00782/full; https://doaj.org/toc/1664-2295 |
| DOI: |
10.3389/fneur.2020.00782 |
| Access URL: |
https://doaj.org/article/c16dc03085f34d1cbc023f6236fa2938 |
| Accession Number: |
edsdoj.16dc03085f34d1cbc023f6236fa2938 |
| Database: |
Directory of Open Access Journals |
