Bibliographic Details
| Title: |
Down syndrome: Distribution of brain amyloid in mild cognitive impairment |
| Authors: |
David B. Keator, Michael J. Phelan, Lisa Taylor, Eric Doran, Sharon Krinsky‐McHale, Julie Price, Erin E. Ballard, William C. Kreisl, Christy Hom, Dana Nguyen, Margaret Pulsifer, Florence Lai, Diana H. Rosas, Adam M. Brickman, Nicole Schupf, Michael A. Yassa, Wayne Silverman, Ira T. Lott |
| Source: |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020) |
| Publisher Information: |
Wiley, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Neurology. Diseases of the nervous system
LCC:Geriatrics |
| Subject Terms: |
ABC‐DS, ADDS, Alzheimer's disease, amyloid, AV‐45, dementia, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6 |
| More Details: |
Abstract Introduction Down syndrome (DS) is associated with a higher risk of dementia. We hypothesize that amyloid beta (Aβ) in specific brain regions differentiates mild cognitive impairment in DS (MCI‐DS) and test these hypotheses using cross‐sectional and longitudinal data. Methods 18F‐AV‐45 (florbetapir) positron emission tomography (PET) data were collected to analyze amyloid burden in 58 participants clinically classified as cognitively stable (CS) or MCI‐DS and 12 longitudinal CS participants. Results The study confirmed our hypotheses of increased amyloid in inferior parietal, lateral occipital, and superior frontal regions as the main effects differentiating MCI‐DS from the CS groups. The largest annualized amyloid increases in longitudinal CS data were in the rostral middle frontal, superior frontal, superior/middle temporal, and posterior cingulate cortices. Discussion This study helps us to understand amyloid in the MCI‐DS transitional state between cognitively stable aging and frank dementia in DS. The spatial distribution of Aβ may be a reliable indicator of MCI‐DS in DS. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2352-8729 |
| Relation: |
https://doaj.org/toc/2352-8729 |
| DOI: |
10.1002/dad2.12013 |
| Access URL: |
https://doaj.org/article/c16ccc9be94a41aca7218ba22d136181 |
| Accession Number: |
edsdoj.16ccc9be94a41aca7218ba22d136181 |
| Database: |
Directory of Open Access Journals |
