Bibliographic Details
| Title: |
A case of severe pulmonary exacerbation in a young patient with cystic fibrosis in the era of CFTR modulators |
| Authors: |
Chiara Lanfranchi, Carmela Rizza, Maria Chiara Russo, Irene Borzani, Salvatore Alessio Angileri, Erica Nazzari, Gianfranco Alicandro, Francesco Blasi, Valeria Daccò |
| Source: |
International Journal of Infectious Diseases, Vol 147, Iss , Pp 107190- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
Bronchial artery embolization, Cystic fibrosis, CFTR modulators, Elexacaftor, Tezacaftor, Ivacaftor, Infectious and parasitic diseases, RC109-216 |
| More Details: |
The introduction of CFTR modulator drugs like elexacaftor-tezacaftor-ivacaftor (ETI) has transformed the management of cystic fibrosis (CF), significantly improving symptoms, lung function, and quality of life, while reducing reliance on intravenous antibiotics. However, respiratory exacerbations in the CFTR modulators era remain poorly understood from both pathophysiological and clinical perspectives.We present the case of a 20-year-old Caucasian woman with CF (F508del/L1077P) who, after three years of ETI treatment, experienced a severe episode of hemoptysis, despite being almost asymptomatic in the weeks leading up to admission, requiring bronchial artery embolization. Following ETI treatment, auscultatory findings and FEV1 changes may be less significant, making the detection of respiratory exacerbation more challenging. This highlights the need for heightened vigilance in managing such cases and underscores the challenge of diagnosing and managing exacerbations in the era of modulators. Long term real-world studies are essential to comprehend the evolving course of the disease during ETI treatment. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1201-9712 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1201971224002613; https://doaj.org/toc/1201-9712 |
| DOI: |
10.1016/j.ijid.2024.107190 |
| Access URL: |
https://doaj.org/article/16c9140f887340b1aa3f2a8d9ce36f1b |
| Accession Number: |
edsdoj.16c9140f887340b1aa3f2a8d9ce36f1b |
| Database: |
Directory of Open Access Journals |
