Bibliographic Details
| Title: |
Transthoracic coronary flow reserve and dobutamine derived myocardial function: a 6-month evaluation after successful coronary angioplasty |
| Authors: |
Pardo Moira, Innelli Pasquale, D'Errico Arcangelo, Guarini Pasquale, Galderisi Maurizio, Cicala Silvana, Scognamiglio Giancarlo, de Divitiis Oreste |
| Source: |
Cardiovascular Ultrasound, Vol 2, Iss 1, p 26 (2004) |
| Publisher Information: |
BMC, 2004. |
| Publication Year: |
2004 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
Percutaneous coronary angioplasty, Coronary flow reserve, Color Tissue Doppler, Stress-echo, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Abstract After percutaneous transluminal coronary angioplasty (PTCA), stress-echocardiography and gated single photon emission computerized tomography (g-SPECT) are usually performed but both tools have technical limitations. The present study evaluated results of PTCA of left anterior descending artery (LAD) six months after PTCA, by combining transthoracic Doppler coronary flow reserve (CFR) and color Tissue Doppler (C-TD) dobutamine stress. Six months after PTCA of LAD, 24 men, free of angiographic evidence of restenosis, underwent standard Doppler-echocardiography, transthoracic CFR of distal LAD (hyperemic to basal diastolic coronary flow ratio) and C-TD at rest and during dobutamine stress to quantify myocardial systolic (Sm) and diastolic (Em and Am, Em/Am ratio) peak velocities in middle posterior septum. Patients with myocardial infarction, coronary stenosis of non-LAD territory and heart failure were excluded. According to dipyridamole g-SPECT, 13 patients had normal perfusion and 11 with perfusion defects. The 2 groups were comparable for age, wall motion score index (WMSI) and C-TD at rest. However, patients with perfusion defects had lower CFR (2.11 ± 0.4 versus 2.87 ± 0.6, p < 0.002) and septal Sm at high-dose dobutamine (p < 0.01), with higher WMSI (p < 0.05) and stress-echo positivity of LAD territory in 5/11 patients. In the overall population, CFR was related negatively to high-dobutamine WMSI (r = -0.50, p < 0.01) and positively to high-dobutamine Sm of middle septum (r = 0.55, p < 0.005). In conclusion, even in absence of epicardial coronary restenosis, stress perfusion imaging reflects a physiologic impairment in coronary microcirculation function whose magnitude is associated with the degree of regional functional impairment detectable by C-TD. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1476-7120 |
| Relation: |
http://www.cardiovascularultrasound.com/content/2/1/26; https://doaj.org/toc/1476-7120 |
| DOI: |
10.1186/1476-7120-2-26 |
| Access URL: |
https://doaj.org/article/16b73c352b32456bb1cf724a5d747c67 |
| Accession Number: |
edsdoj.16b73c352b32456bb1cf724a5d747c67 |
| Database: |
Directory of Open Access Journals |
