Bibliographic Details
| Title: |
110 Clinical Presentations of Adult and Pediatric SARS-CoV-2-Positive Cases in a Community Cohort |
| Authors: |
Danielle A Rankin, Ahmad Yanis, Harrison Howe, Kailee Fernandez, Rana Talj, James D. Chappell, Andrew Speiker, Leigh Howard, Natasha B. Halasa |
| Source: |
Journal of Clinical and Translational Science, Vol 6, Pp 3-3 (2022) |
| Publisher Information: |
Cambridge University Press, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
Medicine |
| More Details: |
OBJECTIVES/GOALS: The spectrum of disease caused by SARS-CoV-2 ranges from asymptomatic detection to severe illness, with varying presentations by age. Therefore, we aimed to compare the clinical characteristics between children and adults with SARS-CoV-2. METHODS/STUDY POPULATION: From March 20, 2020, to August 18, 2021, we conducted SARS-CoV-2 surveillance in individuals from metropolitan Nashville, TN. Children with multisystem inflammatory syndrome were excluded. Analyses were restricted to individuals with SARS-CoV-2 infection confirmed by detection of viral RNA in nasal specimens using reverse-transcription quantitative polymerase chain reaction (RT-qPCR) and/or by detection of serum IgG to the SARS-CoV-2 spike and nucleocapsid proteins using enzyme-linked immunosorbent assay (ELISA). Those with negative RT-qPCR results, but a positive ELISA within 4-6 weeks of symptom onset, were classified as SARS-CoV-2 positive. Clinical characteristics between children and adults were compared with Pearson’s chi square. Illness duration was compared using Kaplan Meier estimators. RESULTS/ANTICIPATED RESULTS: Overall, 426/826 (49%) individuals (children: 57 [13%); adults: 369 [87%]) were SARS-CoV-2 positive, with median ages of 12 and 41 years, respectively. Most individuals were female (54%) and white, non-Hispanic (79%). Compared to adults, children were more likely to be asymptomatic (children: 16% vs. adults: 5%; p=0.001). In contrast, symptomatic adults were more likely to report cough (71% vs. 56%), wheezing (21% vs. 8%), shortness of breath (45% vs. 19%), ageusia (67% vs. 23%), and anosmia (64% vs 27%) than symptomatic children (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2059-8661 |
| Relation: |
https://www.cambridge.org/core/product/identifier/S2059866122000309/type/journal_article; https://doaj.org/toc/2059-8661 |
| DOI: |
10.1017/cts.2022.30 |
| Access URL: |
https://doaj.org/article/16b6ee27e47d49f0ae44f44e73f45e3c |
| Accession Number: |
edsdoj.16b6ee27e47d49f0ae44f44e73f45e3c |
| Database: |
Directory of Open Access Journals |
