Bibliographic Details
| Title: |
Refining the Role of 5-HT in Postnatal Development of Brain Circuits |
| Authors: |
Anne Teissier, Mariano Soiza-Reilly, Patricia Gaspar |
| Source: |
Frontiers in Cellular Neuroscience, Vol 11 (2017) |
| Publisher Information: |
Frontiers Media S.A., 2017. |
| Publication Year: |
2017 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
serotonin transporter, cortex, interneurons, tryptophan hydroxylase, mouse, fluoxetine, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Changing serotonin (5-hydroxytryptamine, 5-HT) brain levels during critical periods in development has long-lasting effects on brain function, particularly on later anxiety/depression-related behaviors in adulthood. A large part of the known developmental effects of 5-HT occur during critical periods of postnatal life, when activity-dependent mechanisms remodel neural circuits. This was first demonstrated for the maturation of sensory brain maps in the barrel cortex and the visual system. More recently this has been extended to the 5-HT raphe circuits themselves and to limbic circuits. Recent studies overviewed here used new genetic models in mice and rats and combined physiological and structural approaches to provide new insights on the cellular and molecular mechanisms controlled by 5-HT during late stages of neural circuit maturation in the raphe projections, the somatosensory cortex and the visual system. Similar mechanisms appear to be also involved in the maturation of limbic circuits such as prefrontal circuits. The latter are of particular relevance to understand the impact of transient 5-HT dysfunction during postnatal life on psychiatric illnesses and emotional disorders in adult life. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1662-5102 |
| Relation: |
http://journal.frontiersin.org/article/10.3389/fncel.2017.00139/full; https://doaj.org/toc/1662-5102 |
| DOI: |
10.3389/fncel.2017.00139 |
| Access URL: |
https://doaj.org/article/16b09e9a57654a749254972b35ba5884 |
| Accession Number: |
edsdoj.16b09e9a57654a749254972b35ba5884 |
| Database: |
Directory of Open Access Journals |
