Intratumoral microbiome is associated with gastric cancer prognosis and therapy efficacy
| Title: | Intratumoral microbiome is associated with gastric cancer prognosis and therapy efficacy |
|---|---|
| Authors: | Gangjian Wang, Haojie Wang, Xin Ji, Tong Wang, Ye Zhang, Wenjie Jiang, Lin Meng, Hua-Jun Wu, Xiaofang Xing, Jiafu Ji |
| Source: | Gut Microbes, Vol 16, Iss 1 (2024) |
| Publisher Information: | Taylor & Francis Group, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: | Prognosis, adjuvant chemotherapy, immunotherapy, microbial subtype, Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: | The role of the intratumoral microbiome in gastric cancer (GC) has not been comprehensively assessed. Here, we explored the relationship between the microbial community and GC prognosis and therapy efficacy. Several cancer-associated microbial characteristics were identified, including increased α-diversity, differential β-diversity, and decreased Helicobacter pylori abundance. After adjusting for clinical features, prognostic analysis revealed 2 phyla, 14 genera, and 5 species associated with the overall survival of patients with GC. Additionally, 2 phyla, 14 genera, and 6 species were associated with adjuvant chemotherapy (ACT) efficacy in patients with stage II – III GC. Furthermore, we classified GC microbiome structures into three microbial subtypes (MS1, MS2 and MS3) with distinguishing features. The MS1 subtype exhibited high immune activity and enrichment of microbiota related to immunotherapy and butyric acid-producing, as well as potential benefits in immunotherapy. MS2 featured the highest α-diversity and activation of the TFF pathway, MS3 was characterized by epithelial-mesenchymal transition and was associated with poor prognosis and reduced ACT efficacy. Collectively, the results of this study provide valuable insights into the microbial characteristics associated with GC prognosis and therapy efficacy. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 19490976 1949-0984 1949-0976 |
| Relation: | https://doaj.org/toc/1949-0976; https://doaj.org/toc/1949-0984 |
| DOI: | 10.1080/19490976.2024.2369336 |
| Access URL: | https://doaj.org/article/a16842ba8af64b54a9c3e226d693e837 |
| Accession Number: | edsdoj.16842ba8af64b54a9c3e226d693e837 |
| Database: | Directory of Open Access Journals |
| ISSN: | 19490976 19490984 |
|---|---|
| DOI: | 10.1080/19490976.2024.2369336 |
| Published in: | Gut Microbes |
| Language: | English |