Bibliographic Details
| Title: |
Elevated Urinary Hepcidin Level and Hypoferremia in Infants with Febrile Urinary Tract Infection: A Prospective Cohort Study |
| Authors: |
Yu-Chen Hsu, Hsin-Chun Huang, Kuo-Su Tang, Li-Ting Su, Ying-Hsien Huang, Hui-Chen Huang, I-Lun Chen |
| Source: |
Children, Vol 10, Iss 5, p 870 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Pediatrics |
| Subject Terms: |
hemoglobin, hepcidin, urine, iron, urinary tract infection, Pediatrics, RJ1-570 |
| More Details: |
To evaluate the kinetics of serum and urinary hepcidin levels along with anemia-related parameters during the infection course of infants with febrile urinary tract infection (UTI), we enrolled febrile infants aged one to four months in this prospective study. Febrile patients with UTI were allocated into Escherichia coli (E. coli) or non-E. coli groups according to urine culture results. Septic workup, blood hepcidin, iron profile, urinalysis, and urinary hepcidin–creatinine ratio were collected upon admission and 3 days after antibiotic treatment. In total, 118 infants were included. On admission, the febrile UTI group showed a significant reduction in serum iron level and a significant elevation of urinary hepcidin–creatinine ratio compared to the febrile control counterpart. Moreover, urinary hepcidin–creatinine ratio had the highest odds ratio, 2.01, in logistics regression analysis. After 3 days of antibiotic treatment, hemoglobin and the urinary hepcidin–creatinine ratio were significantly decreased. Patients with an E. coli UTI had a significantly decreased urinary hepcidin–creatinine ratio after 3 days of antibiotics treatment, whereas the non-E. coli group showed insignificant changes. Our study suggested that the urinary hepcidin–creatinine ratio elevated during acute febrile urinary tract infection and significantly decreased after 3 days of antibiotics treatment, especially in E. coli UTI. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2227-9067 |
| Relation: |
https://www.mdpi.com/2227-9067/10/5/870; https://doaj.org/toc/2227-9067 |
| DOI: |
10.3390/children10050870 |
| Access URL: |
https://doaj.org/article/15bad50bb8344737ab640d8f8d42ca8f |
| Accession Number: |
edsdoj.15bad50bb8344737ab640d8f8d42ca8f |
| Database: |
Directory of Open Access Journals |
