Bibliographic Details
| Title: |
Association between systemic lupus erythematosus and osteoporosis: a mendelian randomization analysis |
| Authors: |
Danfeng Xu, Bing Wu |
| Source: |
BMC Rheumatology, Vol 8, Iss 1, Pp 1-9 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Diseases of the musculoskeletal system |
| Subject Terms: |
Mendelian randomization, Systemic lupus erythematosus, Osteoporosis, Causal relationship, Diseases of the musculoskeletal system, RC925-935 |
| More Details: |
Abstract Background Systemic Lupus Erythematosus (SLE) and Osteoporosis are two prevalent medical conditions. Previous studies have suggested a possible correlation between SLE and osteoporosis, though the underpinning causal relationship remains largely unknown. The current study aimed to elucidate the causal association between SLE and osteoporosis by employing a Mendelian randomization (MR) approach. Methods We performed two-sample MR analysis using the inverse variance-weighted (IVW), weighted median, and MR-Egger methods on publicly available summary statistics datasets using a SLE genome-wide association study (GWAS) as an exposure and osteoporosis GWASs in people with East Asia ancestry as outcomes. The pleiotropy and heterogeneity were examined using a variety of techniques, including the MR-Egger intercept, the MR-PRESSO approach, and the Cochran’s Q test. Results We selected 26 single-nucleotide polymorphisms from a SLE GWAS as instrumental variables for osteoporosis. The IVW (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2520-1026 |
| Relation: |
https://doaj.org/toc/2520-1026 |
| DOI: |
10.1186/s41927-024-00388-5 |
| Access URL: |
https://doaj.org/article/15357603877a4ec0b80b9ebb97192885 |
| Accession Number: |
edsdoj.15357603877a4ec0b80b9ebb97192885 |
| Database: |
Directory of Open Access Journals |
