Impact of Hydroxy‐Methyl‐Butyrate Supplementation on Malnourished Patients Assessed Using AI‐Enhanced Ultrasound Imaging
| Title: | Impact of Hydroxy‐Methyl‐Butyrate Supplementation on Malnourished Patients Assessed Using AI‐Enhanced Ultrasound Imaging |
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| Authors: | Daniel deLuis, Angela Cebria, David Primo, Sara Nozal, Olatz Izaola, Eduardo Jorge Godoy, Juan Jose Lopez Gomez |
| Source: | Journal of Cachexia, Sarcopenia and Muscle, Vol 16, Iss 1, Pp n/a-n/a (2025) |
| Publisher Information: | Wiley, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Diseases of the musculoskeletal system LCC:Human anatomy |
| Subject Terms: | artificial intelligence, disease‐related malnutrition (DRM), hydroxy‐methyl‐butyrate (HMB), oral nutritional supplement (ONS), ultrasound‐imaging, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695 |
| More Details: | ABSTRACT Background This study aimed to evaluate the effects of an oral nutritional supplement (ONS) enriched with hydroxy‐methyl‐butyrate (HMB) in subjects with disease‐related malnutrition (DRM) and to monitor these effects with an ultrasound Imaging System, based on artificial intelligence, in a real‐world study. Methods Fifty consecutive adult patients with DRM were enrolled. The malnutrition was diagnosed by Global Leadership Initiative on Malnutrition (GLIM) criteria. For 3 months, the patients received nutritional education, and medical nutrition therapy was started with an adapted oral diet and two servings of an oral nutritional supplementation (ONS) with a hyperproteic hypercaloric formula (HMB—enriched). All patients were studied at baseline, and 3 months after intervention, with a nutritional assessment (anthropometry, bioelectrical impedanciometry [BIA], muscle ultrasonography and biochemical parameters). Ultrasound images were automatically quantified using an AI‐based ultrasound imaging system. Results The study included 50 patients (21 men and 29 women) with a mean age of 57.8 ± 18.1 years. Following treatment with the HMB‐enriched ONS, the prevalence of sarcopenia decreased significantly (from 24% to 18%; p = 0.01) and severe malnutrition (from 14% to 2%; p = 0.01). An improvement in BIA parameters; phase angle (0.14 ± 0.02°; p = 0.02); phase angle index (0.07 ± 0.01°/m2; p = 0.01); fat free mass (1.31 ± 0.12 kg; p = 0.006); skeletal muscle mass (0.51 ± 0.11 kg; p = 0.01); and skeletal muscle mass index (0.31 ± 0.13 kg/m2; p = 0.01) were reported. Functional parameters as handgrip strength (1.36 ± 0.21 kg; p = 0.009) and seconds of time up and go test (1.16 ± 0.15 s; p = 0.02) showed also an improvement. The AI‐based ultrasound system detected a significant increase in the thickness of the vastus intermedius muscle (TVI) (0.09 ± 0.01 cm; p = 0.008) and an increase of the rectus femoris (TRF) (1.06 ± 0.4 cm; p = 0.07) with the consequence of a significant increase of the (TVITRF) (0.15 ± 0.02 cm; p = 0.008). The sarcopenia index is also significant (1.03 ± 0.3 cm; p = 0.03). Muscle quality, as assessed by echogenicity analysis, improved significantly: muscle index (Mi) (0.04 ± 0.01; p = 0.04) and (fat index) FATi (−0.03 ± 0.01; p = 0.03). Conclusions The use of an HMB‐enriched ONS in DRM patients, combined with AI‐based ultrasound imaging for follow‐up, significantly improved their nutritional status, muscle mass and muscle quality as assessed by echogenicity. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2190-6009 2190-5991 |
| Relation: | https://doaj.org/toc/2190-5991; https://doaj.org/toc/2190-6009 |
| DOI: | 10.1002/jcsm.13700 |
| Access URL: | https://doaj.org/article/151cad7f527d46d98ef4506680be002e |
| Accession Number: | edsdoj.151cad7f527d46d98ef4506680be002e |
| Database: | Directory of Open Access Journals |
| ISSN: | 21906009 21905991 |
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| DOI: | 10.1002/jcsm.13700 |
| Published in: | Journal of Cachexia, Sarcopenia and Muscle |
| Language: | English |