Bibliographic Details
| Title: |
Role of Endogenous Opioid System in Ischemic-Induced Late Preconditioning. |
| Authors: |
Jan Fraessdorf, Markus W Hollmann, Iris Hanschmann, André Heinen, Nina C Weber, Benedikt Preckel, Ragnar Huhn |
| Source: |
PLoS ONE, Vol 10, Iss 7, p e0134283 (2015) |
| Publisher Information: |
Public Library of Science (PLoS), 2015. |
| Publication Year: |
2015 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
Opioid receptors (OR) are involved in myocardial late preconditioning (LPC) induced by morphine and δ1-opioid receptor (δ1-OR) agonists. The role of OR in ischemic-induced LPC is unknown. We investigated whether 1) OR are involved in the trigger and/or mediation phase of LPC and 2) a time course effect on the expression of different opioid receptors and their endogenous ligands exists.Male Wistar rats were randomly allocated to four groups (each group n = 8). Awake animals were ischemic preconditioned by a 5 minutes coronary occlusion. 24 hours later, anesthetized animals underwent 25 minutes coronary occlusion followed by 2 hours of reperfusion. The role of OR was investigated by treatment with intraperitoneal naloxone (Nal) 10 minutes prior to LPC (Nal-LPC; trigger phase) or 10 min prior to sustained ischemia (LPC-Nal; mediation phase).LPC reduced infarct size from 61±10% in controls to 25±9% (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
http://europepmc.org/articles/PMC4520665?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0134283 |
| Access URL: |
https://doaj.org/article/14f07c05db624dc7a5bcfef7d770ddce |
| Accession Number: |
edsdoj.14f07c05db624dc7a5bcfef7d770ddce |
| Database: |
Directory of Open Access Journals |
