Renexin as a rescue regimen for noise-induced hearing loss
| Title: | Renexin as a rescue regimen for noise-induced hearing loss |
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| Authors: | So Young Park, Sang A Back, Hong Lim Kim, Dong Kee Kim, Sang Won Yeo, Shi Nae Park |
| Source: | Noise and Health, Vol 16, Iss 72, Pp 257-264 (2014) |
| Publisher Information: | Wolters Kluwer Medknow Publications, 2014. |
| Publication Year: | 2014 |
| Collection: | LCC:Otorhinolaryngology LCC:Industrial medicine. Industrial hygiene |
| Subject Terms: | Antioxidant, cilostazol, ginkgo biloba extract, medial olivocochlear efferent, organ of Corti, α -synuclein, Otorhinolaryngology, RF1-547, Industrial medicine. Industrial hygiene, RC963-969 |
| More Details: | Renexin, a compound of cilostazol and ginkgo biloba extract, has been reported to produce neuroprotective effects through antioxidant, antiplatelet, and vasodilatory mechanisms. This study was designed to investigate the protective effects of renexin on hearing, the organ of Corti (OC), and medial olivocochlear efferents against noise-induced damage. C57BL/6 mice were exposed to 110 dB SPL white noise for 60 min and then randomly divided into three groups: high- and low-dose renexin-treated groups and noise only group. Renexin were administered for 7 days: 90 mg/kg to the low-dose, and 180 mg/kg to the high-dose groups. All mice, including the controls underwent hearing tests on postnoise day 8 and were killed for cochlear harvest. We compared the hearing thresholds and morphology of the OC and cochlear efferents across the groups. The renexin-treated groups recovered from the immediate threshold shifts in a dose-dependent manner, while the noise group showed a permanent hearing loss. The renexin-treated ears demonstrated less degeneration of the OC. The diameters of the efferent terminals labeled with α-synuclein were preserved in the high-dose renexin-treated group. In the western blot assay of the cochlear homogenates, the treated groups displayed stronger expressions of α-synuclein than the noise and control groups, which may indicate that noise-induced enhanced activity of the cochlear efferent system was protected by renexin. Our results suggest that pharmacologic treatment with renexin is hopeful to reduce or prevent noise-induced hearing loss as a rescue regimen after noise exposure. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1463-1741 1998-4030 |
| Relation: | http://www.noiseandhealth.org/article.asp?issn=1463-1741;year=2014;volume=16;issue=72;spage=257;epage=264;aulast=Park; https://doaj.org/toc/1463-1741; https://doaj.org/toc/1998-4030 |
| DOI: | 10.4103/1463-1741.140497 |
| Access URL: | https://doaj.org/article/14abe80b84544ee197a35eb22ad561b4 |
| Accession Number: | edsdoj.14abe80b84544ee197a35eb22ad561b4 |
| Database: | Directory of Open Access Journals |
| ISSN: | 14631741 19984030 |
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| DOI: | 10.4103/1463-1741.140497 |
| Published in: | Noise and Health |
| Language: | English |