Single brain metastases – prognostic factors and impact of residual tumor burden on overall survival
| Title: | Single brain metastases – prognostic factors and impact of residual tumor burden on overall survival |
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| Authors: | Lea Baumgart, Aida Anetsberger, Amir Kaywan Aftahy, Benedikt Wiestler, Denise Bernhardt, Stephanie E. Combs, Hanno S. Meyer, Gerhard Schneider, Bernhard Meyer, Jens Gempt |
| Source: | Frontiers in Oncology, Vol 14 (2024) |
| Publisher Information: | Frontiers Media S.A., 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | single brain metastasis, neurooncology, postoperative tumor volume, brain metastasis, postoperative MRI, extent of resection, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | BackgroundBrain metastases (BM) are a common and challenging issue, with their incidence on the rise due to advancements in systemic therapies and increased patient survival. Most patients present with single BM, some of them without any further extracranial metastasis (i.e., solitary BM). The significance of postoperative intracranial tumor volume in the treatment of singular and solitary BM is still debated.ObjectiveThis study aimed to determine the impact of resection and postoperative tumor burden on overall survival (OS) in patients with single BM.MethodsPatients with surgically treated single BM between 04/2007-01/2020 were retrospectively included. Residual tumor burden (RTB) was determined by manual segmentation of early postoperative brain MRI (72 h). Survival analyses were performed using Kaplan-Meier estimates for univariate analysis and Cox regression proportional hazards model for multivariate analysis, using preoperative Karnofsky performance status scale (KPSS), age, sex, RTB, incomplete resection and singular/solitary BM as covariates.Results340 patients were included, median age 64 years (54-71). 119 patients (35%) had solitary BM, 221 (65%) singular BM. Complete resection (RTB=0) was achieved in 73%, median preoperative tumor burden was 11.2 cm3 (5-25), and RTB 0 cm3 (0-0.2). Median OS of patients with singular BM was 13 months (4-33) vs 20 months (5-92) for solitary BM; p=0.062. Multivariate analysis revealed singular BM as independent risk factor for poorer OS: HR 1.840 (1.202-2.817), p=0.005. Complete vs. incomplete resection showed no significant OS difference (13 vs. 13 months, p=0.737). When focusing on solitary BM, complete resection led to a longer OS than incomplete resection (21 vs. 8 months), without statistical significance(p=0.250). Achieving RTB=0 resulted in higher OS for patients with solitary BM compared to singular BM (21 vs. 12 months, p=0.027). Patients who received postoperative radiotherapy (RT) had significantly longer OS compared to those without it (14 vs. 4 months, p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2234-943X 53731123 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1330492/full; https://doaj.org/toc/2234-943X |
| DOI: | 10.3389/fonc.2024.1330492 |
| Access URL: | https://doaj.org/article/14666efe07d54c549dd537311230e127 |
| Accession Number: | edsdoj.14666efe07d54c549dd537311230e127 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2234943X 53731123 |
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| DOI: | 10.3389/fonc.2024.1330492 |
| Published in: | Frontiers in Oncology |
| Language: | English |