Bibliographic Details
| Title: |
Impaired cutaneous T-cell attracting chemokine elevation and adipose-derived stromal cell migration in a high-glucose environment cause poor diabetic wound healing |
| Authors: |
Wei-Ting Wang, Su-Shin Lee, Ya-Chin Wang, Ya-Wei Lai, Yur-Ren Kuo, Yueh-Bih Tang Chen, Yu-Sen Liu, Yi-Chia Wu |
| Source: |
Kaohsiung Journal of Medical Sciences, Vol 34, Iss 10, Pp 539-546 (2018) |
| Publisher Information: |
Wiley, 2018. |
| Publication Year: |
2018 |
| Collection: |
LCC:Medicine (General) |
| Subject Terms: |
Medicine (General), R5-920 |
| More Details: |
Diabetic wound care is a major health care concern. The major cause of non-healing of wounds in patients with diabetes mellitus (DM) patients mainly involves poor glycemic control, which hinders the migration of progenitor cells including mesenchymal stem cells to the wound site. In this study, we introduced adipose-derived stromal cells (ADSCs) into wound sites and demonstrated that the local transplantation of ADSCs accelerated DM-related wound healing. Furthermore, the migration ability of ADSCs, which diminishes in a high-glucose environment, was partially restored by the exogenous replenishment of the cutaneous T-cell attracting chemokine (CTACK/CCL27). Our findings suggest that CTACK is a potential novel therapeutic target in DM-related wound healing. Keywords: ADSC, CTACK/CCL27, Diabetes mellitus, Wound |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1607-551X |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1607551X18301682; https://doaj.org/toc/1607-551X |
| DOI: |
10.1016/j.kjms.2018.05.002 |
| Access URL: |
https://doaj.org/article/145152d492834205ae9144beefabedc2 |
| Accession Number: |
edsdoj.145152d492834205ae9144beefabedc2 |
| Database: |
Directory of Open Access Journals |
