Bibliographic Details
| Title: |
Characterization and comparative evaluation of wound healing potential of Ajugarin I and Ajuga bracteosa Wall. ex Benth |
| Authors: |
Yusra Wasti, Durdana Muntaqua, Muhammad Majid, Iffat Naz, Aroosa Zafar, Safir Ullah Khan, Syeda Tayyaba Batool Kazmi, Tofeeq Ur Rehman, Nadeem Irshad, Humaira Fatima |
| Source: |
Frontiers in Chemistry, Vol 11 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Chemistry |
| Subject Terms: |
Ajuga species, Ajugarin I, polyphenols, high pressure liquid chromatography, wound healing, Chemistry, QD1-999 |
| More Details: |
Ajuga bracteosa (family: Lamiaceae), commonly known as kauri booti, is an important ethnomedicinal plant. The current research was conducted to appraise and compare the in vitro antioxidant and antibacterial profiles as well as in vivo wound healing potentials of Ajugarin I and A. bracteosa extract. Ajugarin I and polyphenols in A. bracteosa were enumerated by reversed-phase high-performance liquid chromatography analysis that confirmed significant amounts of Ajugarin I (2.2 ± 0.02 μg/mg DW) and other phenolic compounds (14 out of 17 standards). A. bracteosa (374.4 ± 0.20 µg AAE/mg of DW, 201.9 ± 0.20 µg AAE/mg of DW, 87 ± 0.30%) showed a higher antioxidant profile compared to Ajugarin I (221.8 ± 0.50 µg AAE/mg of DW, 51.8 ± 0.40 µg AAE/mg of DW, 27.65 ± 0.80%) with 1.86-, 3.89-, and 3.15-fold greater activity in ferric reducing antioxidant power, total antioxidant capacity, and free radical scavenging assays, respectively. Likewise, A. bracteosa showed antibacterial activity against 3/5 strains (MIC 25–200 μg/ml) than Ajugarin I (2/5 strains; MIC 50–200 μg/ml). Hemolytic ( |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2296-2646 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fchem.2023.1325578/full; https://doaj.org/toc/2296-2646 |
| DOI: |
10.3389/fchem.2023.1325578 |
| Access URL: |
https://doaj.org/article/144d5059287349bbbd8798ab057dda71 |
| Accession Number: |
edsdoj.144d5059287349bbbd8798ab057dda71 |
| Database: |
Directory of Open Access Journals |
