Bibliographic Details
| Title: |
High incidence of atrial fibrillation in patients treated with ibrutinib |
| Authors: |
Florian Baptiste, Jennifer Cautela, Yan Ancedy, Noémie Resseguier, Thérèse Aurran, Laure Farnault, Marion Escudier, Chloé Ammar, Mélanie Gaubert, Charles Dolladille, Jeremie Barraud, Michael Peyrol, Ariel Cohen, Franck Paganelli, Joachim Alexandre, Stephane Ederhy, Franck Thuny |
| Source: |
Open Heart, Vol 6, Iss 1 (2019) |
| Publisher Information: |
BMJ Publishing Group, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Objective Atrial fibrillation (AF) is one of the most common side effects of ibrutinib, a drug that has dramatically improved the prognosis of chronic B-cell malignancies such as chronic lymphocytic leukaemia (CLL). The true incidence of ibrutinib-related AF (IRAF) is not well known and its therapeutic management poses unique challenges especially due to the inherent risk of bleeding. We aimed to determine the incidence and predictors of IRAF, and to analyse its management and outcome.Methods A standardised monitoring was applied at two cardio-oncology clinics in consecutive patients referred before and during ibrutinib therapy. The primary endpoint was the incidence of IRAF. The excess of AF incidence with ibrutinib was studied by comparing the incidence of IRAF with the expected incidence of AF in general population and in patients with CLL not exposed to ibrutinib.Results 53 patients were included. The incidence of IRAF was 38% at 2 years and the risk was 15-fold higher than the AF risk in both the general population and patients with CLL not exposed to ibrutinib (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2053-3624 |
| Relation: |
https://openheart.bmj.com/content/6/1/e001049.full; https://doaj.org/toc/2053-3624 |
| DOI: |
10.1136/openhrt-2019-001049 |
| Access URL: |
https://doaj.org/article/e141364c960c483e884ff8da784b3ca4 |
| Accession Number: |
edsdoj.141364c960c483e884ff8da784b3ca4 |
| Database: |
Directory of Open Access Journals |
