Bibliographic Details
| Title: |
Very high HDL-C (high-density lipoprotein cholesterol) is associated with increased cardiovascular risk in patients with NSTEMI (non-ST-segment elevation myocardial infarction) undergoing PCI (percutaneous coronary intervention) |
| Authors: |
Lijuan Chen, Yuanyuan Zhao, Zheng Wang, Yifei Wang, Xiangwei Bo, Xiaoxi Jiang, Chunshu Hao, Chengwei Ju, Yangyang Qu, Hongjian Dong |
| Source: |
BMC Cardiovascular Disorders, Vol 23, Iss 1, Pp 1-8 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
Cholesterol, High-density lipoprotein, Dyslipidemia, Percutaneous coronary intervention, MACCE, NSTEMI, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Abstract Background Studies in populations with or without cardiovascular disease have shown that very high HDL-C levels are associated with an increased risk of cardiovascular events. However, the exact relationship between HDL-C levels and long-term prognosis remains unknown in patients with myocardial infarction (MI) undergoing percutaneous coronary intervention (PCI). Methods This was a post hoc secondary analysis of long-term follow-up results in patients undergoing PCI open-label, observational cohort study. Patients with MI who had undergone PCI were enrolled. Restricted cubic spline (RCS) analysis and logistic regression analysis were performed to assess the relationship between HDL-C levels and the risk of cardiovascular events. Results A total of 1934 patients with MI undergoing PCI were enrolled in our analysis and our population was divided in 3 groups according to the HDL-C plasma levels: HDL-C 80 mg/dL (high HDL-C). RCS analysis showed a nonlinear U-shaped association between HDL-C levels and major adverse cardiac and cerebrovascular events (MACCE) in patients with NSTEMI with adjusted variables. After adjusting for potential confounders, the follow-up analysis indicated that high risk group had elevated occurrence of MACCE than low risk group (HDL-C 35 and 55 mg/dL) (OR:1.645, P = 0.006). Conclusions Our analysis demonstrated that there is a U-shaped association between HDL-C and MACCE in patients with NSTEMI undergoing PCI. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2261 |
| Relation: |
https://doaj.org/toc/1471-2261 |
| DOI: |
10.1186/s12872-023-03383-9 |
| Access URL: |
https://doaj.org/article/13746ed026e14d8fb3425911006d722f |
| Accession Number: |
edsdoj.13746ed026e14d8fb3425911006d722f |
| Database: |
Directory of Open Access Journals |
