Bibliographic Details
| Title: |
The modulatory effects of Lonicera caerulea L. extract and omega-3 on sarcopenia via regulating PI3K and FOXO signaling pathways in rats |
| Authors: |
Radwa Wahid Mohamed, Nourhan Gamal El-Rahmany |
| Source: |
Journal of HerbMed Pharmacology, Vol 13, Iss 4, Pp 651-658 (2024) |
| Publisher Information: |
Shahrekord University of Medical Sciences, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine (General)
LCC:Therapeutics. Pharmacology |
| Subject Terms: |
cathepsin, dexamethasone, muscle atrophy, atrogin-1, haskap berry, nuclear factor kappa b, oxidative damage, Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950 |
| More Details: |
Introduction: Sarcopenia is an inflammatory disease caused by a disruption of muscle homeostasis. Lonicera caerulea L. (Haskap berry) (HB) extract and omega-3 (ω−3) possess antioxidant and anti-inflammatory activities. This study assesses the potential ameliorating effects of HB extract and ω−3 supplementation on dexamethasone (DEXA)-induced sarcopenia. Methods: Rats were divided into five groups; the negative control group was injected with saline (i.p.); groups 2, 3, 4, and 5 were injected with DEXA (2 mg/kg/d, i.p.); groups 3 and 4 also received 400 mg/kg/d and 100 mg/kg/d of HB extract and ω−3, respectively, while group 5 received both treatments daily for 21 days. The ameliorative effects of treatments were investigated by measuring lysosomal proteolytic enzyme cathepsin activity, phosphatidylinositol 3 kinase (PI3K) activity, nuclear factor kappa beta (NF-κB) level, and heme oxygenase-1 (HO-1) activity. The gene expression levels of muscle ring-finger protein (MuRF) and forkhead box O (FOXO) transcription factor were also evaluated. Biochemical and histological examinations were done on muscle tissues. Results: DEXA caused a significant elevation (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2345-5004 |
| Relation: |
https://herbmedpharmacol.com/PDF/jhp-13-651.pdf; https://doaj.org/toc/2345-5004 |
| DOI: |
10.34172/jhp.2024.52596 |
| Access URL: |
https://doaj.org/article/dc136b9c1afc4da4b9cb1b106c7ea313 |
| Accession Number: |
edsdoj.136b9c1afc4da4b9cb1b106c7ea313 |
| Database: |
Directory of Open Access Journals |
