Bibliographic Details
| Title: |
Triglyceride Saturation in Patients at Risk of NASH and NAFLD: A Cross-Sectional Study |
| Authors: |
Mark Bydder, Tanya Chavez, Jessica Lam, Walter Henderson, Nick Pinto, Roxana Chavarria, Alex D. Pham, Rohit Loomba, Jeff Schwimmer, Claude Sirlin, Gavin Hamilton |
| Source: |
Biophysica, Vol 2, Iss 1, Pp 8-15 (2021) |
| Publisher Information: |
MDPI AG, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
triglyceride, MRI, PDFF, adipose tissue, Biology (General), QH301-705.5 |
| More Details: |
Chemical shift magnetic resonance imaging (MRI) is commonly used to estimate the amount of fat in tissues, namely the proton density fat fraction (PDFF). In addition to PDFF, the type of fat can be inferred and characterized in terms of the number of double bonds (NDB), number of methylene-interrupted double bonds (NMIDB) and the chain length (CL) of the fatty acid chains. The saturation index is potentially a marker for metabolic disorders. This study assesses the feasibility of estimating these parameters independently or in a constrained manner. Correlations with spectroscopy were measured in 109 subjects’ subcutaneous and visceral fat depots (p = 2 × 10−28), and with the NAFLD Activity Score (NAS) from histological evaluation of biopsies. The findings indicate that imaging estimates are comparable to spectroscopy (p = 0.0002), but there is no significant association of NDB with NAS (p = 0.1). |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2673-4125 |
| Relation: |
https://www.mdpi.com/2673-4125/2/1/2; https://doaj.org/toc/2673-4125 |
| DOI: |
10.3390/biophysica2010002 |
| Access URL: |
https://doaj.org/article/e12f17d52169465a957ffc6dd4ada98e |
| Accession Number: |
edsdoj.12f17d52169465a957ffc6dd4ada98e |
| Database: |
Directory of Open Access Journals |
