Oral microbiome in older adults with mild cognitive impairment
| Title: | Oral microbiome in older adults with mild cognitive impairment |
|---|---|
| Authors: | Dongxin Da, Qianhua Zhao, Hao Zhang, Wanqing Wu, Xiaoli Zeng, Xiaoniu Liang, Yiwei Jiang, Zhenxu Xiao, Jin Yu, Saineng Ding, Li Zheng, Ying Zhang, Xiaogang Xu, Ding Ding |
| Source: | Journal of Oral Microbiology, Vol 15, Iss 1 (2023) |
| Publisher Information: | Taylor & Francis Group, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Infectious and parasitic diseases LCC:Microbiology |
| Subject Terms: | Oral microbiome, mild cognitive impairment, older adults, 16S rDNA, bioinformatic analysis, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502 |
| More Details: | ABSTRACTThe association between the oral microbiome and mild cognitive impairment (MCI) remains unclear. This study aimed to investigate such an association among Chinese older adults. Participants without dementia were recruited from the community. A battery of neuropsychological tests was administered to evaluate the cognitive function. The diagnosis of MCI was based on Peterson’s criteria. The non-stimulated saliva was collected to extract sequences of the oral microbiome. Forty-seven MCI and 47 cognitively normal participants were included. There was significant difference in alpha diversity and insignificant difference in beta diversity between the two groups of participants. Compared with the cognitively normal group, Gemella haemolysans and Streptococcus gordonii were two significantly decreased species while Veillonella unclassified_Veillonella and Fusobacterium sp._HMT_203 were two significantly increased species in the MCI group. The richness of Gemella haemolysans presented the best discriminate value for MCI with the AUC (Area Under Curve) of 0.707, a cut-off value of 0.008 for relative abundance, the sensitivity of 63.8% and specificity of 70.2%. The dysbiosis of oral microbiome and relative abundance of Gemella haemolysans was significantly associated with MCI. Further studies were needed to develop new treatment strategies targeting the oral microbiome for cognitive impairment. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 20002297 2000-2297 |
| Relation: | https://doaj.org/toc/2000-2297 |
| DOI: | 10.1080/20002297.2023.2173544 |
| Access URL: | https://doaj.org/article/12f158a5253c4863af9ba85387afef5e |
| Accession Number: | edsdoj.12f158a5253c4863af9ba85387afef5e |
| Database: | Directory of Open Access Journals |
| ISSN: | 20002297 |
|---|---|
| DOI: | 10.1080/20002297.2023.2173544 |
| Published in: | Journal of Oral Microbiology |
| Language: | English |