Activation of the Coagulation Cascade as a Universal Danger Sign
| Title: | Activation of the Coagulation Cascade as a Universal Danger Sign |
|---|---|
| Authors: | Eleonora A. Starikova, Jennet T. Mammedova, Artem A. Rubinstein, Alexey V. Sokolov, Igor V. Kudryavtsev |
| Source: | Current Issues in Molecular Biology, Vol 47, Iss 2, p 108 (2025) |
| Publisher Information: | MDPI AG, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Biology (General) |
| Subject Terms: | coagulation and immunity, factor XII, thrombin, fibrinogen, PAMPs, DAMPs, Biology (General), QH301-705.5 |
| More Details: | Hemostasis is a mechanism that stops bleeding from an injured vessel, involves multiple interlinked steps, culminating in the formation of a “clot” sealing the damaged area. Moreover, it has long been recognized that inflammation also provokes the activation of the coagulation system. However, there has been an increasing amount of evidence revealing the immune function of the hemostasis system. This review collects and analyzes the results of the experimental studies and data from clinical observations confirming the inflammatory function of hemostasis. Here, we summarize the latest knowledge of the pathways in immune system activation under the influence of coagulation factors. The data analyzed allow us to consider the components of hemostasis as receptors recognizing «foreign» or damaged «self» or/and as «self» damage signals that initiate and reinforce inflammation and affect the direction of the adaptive immune response. To sum up, the findings collected in the review allow us to classify the coagulation factors, such as Damage-Associated Molecular Patterns that break down the conventional concepts of the coagulation system. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1467-3045 1467-3037 |
| Relation: | https://www.mdpi.com/1467-3045/47/2/108; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045 |
| DOI: | 10.3390/cimb47020108 |
| Access URL: | https://doaj.org/article/12f0e9ddb9f047c9857e6ce51a79aad1 |
| Accession Number: | edsdoj.12f0e9ddb9f047c9857e6ce51a79aad1 |
| Database: | Directory of Open Access Journals |
| ISSN: | 14673045 14673037 |
|---|---|
| DOI: | 10.3390/cimb47020108 |
| Published in: | Current Issues in Molecular Biology |
| Language: | English |