Bibliographic Details
| Title: |
Children’s Oxygen Administration Strategies And Nutrition Trial (COAST-Nutrition): a protocol for a phase II randomised controlled trial [version 2; peer review: 2 approved] |
| Authors: |
Sarah Kiguli, Peter Olopot-Olupot, Florence Alaroker, Charles Engoru, Robert O. Opoka, Abner Tagoola, Mainga Hamaluba, Hellen Mnjalla, Ayub Mpoya, Christabel Mogaka, Damalie Nalwanga, Eva Nabawanuka, James Nokes, Charles Nyaigoti, André Briend, Job B. M. van Woensel, Richard Grieve, Zia Sadique, Thomas N. Williams, Karen Thomas, David A. Harrison, Kathryn Rowan, Kathryn Maitland |
| Source: |
Wellcome Open Research, Vol 6 (2021) |
| Publisher Information: |
Wellcome, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
Background: To prevent poor long-term outcomes (deaths and readmissions) the integrated global action plan for pneumonia and diarrhoea recommends under the ‘Treat’ element of Protect, Prevent and Treat interventions the importance of continued feeding but gives no specific recommendations for nutritional support. Early nutritional support has been practiced in a wide variety of critically ill patients to provide vital cell substrates, antioxidants, vitamins, and minerals essential for normal cell function and decreasing hypermetabolism. We hypothesise that the excess post-discharge mortality associated with pneumonia may relate to the catabolic response and muscle wasting induced by severe infection and inadequacy of the diet to aid recovery. We suggest that providing additional energy-rich, protein, fat and micronutrient ready-to-use therapeutic feeds (RUTF) to help meet additional nutritional requirements may improve outcome. Methods: COAST-Nutrition is an open, multicentre, Phase II randomised controlled trial in children aged 6 months to 12 years hospitalised with suspected severe pneumonia (and hypoxaemia, SpO2 |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2398-502X |
| Relation: |
https://wellcomeopenresearch.org/articles/6-221/v2; https://doaj.org/toc/2398-502X |
| DOI: |
10.12688/wellcomeopenres.17123.2 |
| Access URL: |
https://doaj.org/article/129c2b6aa4b1466f97844c56850d74e4 |
| Accession Number: |
edsdoj.129c2b6aa4b1466f97844c56850d74e4 |
| Database: |
Directory of Open Access Journals |
