Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia

Bibliographic Details
Title:	Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia
Authors:	Madeline R. Scott, Wei Zong, Kyle D. Ketchesin, Marianne L. Seney, George C. Tseng, Bokai Zhu, Colleen A. McClung
Source:	PLoS Biology, Vol 21, Iss 1 (2023)
Publisher Information:	Public Library of Science (PLoS), 2023.
Publication Year:	2023
Collection:	LCC:Biology (General)
Subject Terms:	Biology (General), QH301-705.5
More Details:	Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology, no study has measured 12 h rhythms in the human brain. Here, we identify 12 h rhythms in transcripts that either peak at sleep/wake transitions (approximately 9 AM/PM) or static times (approximately 3 PM/AM) in the dorsolateral prefrontal cortex, a region involved in cognition. Subjects with schizophrenia (SZ) lose 12 h rhythms in genes associated with the unfolded protein response and neuronal structural maintenance. Moreover, genes involved in mitochondrial function and protein translation, which normally peak at sleep/wake transitions, peak instead at static times in SZ, suggesting suboptimal timing of these essential processes.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1544-9173 1545-7885
Relation:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873190/?tool=EBI; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885
Access URL:	https://doaj.org/article/11d0eed8e2854161b9ebe473ec5f6fe8
Accession Number:	edsdoj.11d0eed8e2854161b9ebe473ec5f6fe8
Database:	Directory of Open Access Journals
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More Details
ISSN:	15449173 15457885
Published in:	PLoS Biology
Language:	English