Bibliographic Details
| Title: |
Rapid screening and early precautions for carbapenem-resistant Acinetobacter baumannii carriers decreased nosocomial transmission in hospital settings: a quasi-experimental study |
| Authors: |
Norihisa Yamamoto, Shigeto Hamaguchi, Yukihiro Akeda, Pitak Santanirand, Narong Chaihongsa, Suntariya Sirichot, Suwichak Chiaranaicharoen, Hideharu Hagiya, Kouji Yamamoto, Anusak Kerdsin, Kazuhisa Okada, Hisao Yoshida, Shigeyuki Hamada, Kazunori Oishi, Kumthorn Malathum, Kazunori Tomono |
| Source: |
Antimicrobial Resistance and Infection Control, Vol 8, Iss 1, Pp 1-8 (2019) |
| Publisher Information: |
BMC, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
Carbapenem-resistant Acinetobacter baumannii (CRAB), Nosocomial transmission, LAMP (Loop-mediated isothermal amplification), Rapid molecular diagnosis., Rapid intervention, Intensive care unit., Infectious and parasitic diseases, RC109-216 |
| More Details: |
Abstract Background Active surveillance has the potential to prevent nosocomial transmission of carbapenem-resistant Acinetobacter baumannii (CRAB). We assessed whether rapid diagnosis using clinical specimen-direct loop-mediated isothermal amplification (LAMP), a rapid molecular diagnostic assay, and subsequent intervention, could reduce CRAB nosocomial transmission in intensive care units (ICUs). Methods A before and after (quasi-experimental) study was conducted in two ICUs at the Mahidol University Faculty of Medicine Ramathibodi Hospital with 3 months of observational period followed by 9 months of interventional period. All patients were screened for CRAB using both the culture and LAMP method from rectal swab and/or bronchial aspirates (intubated patients only) upon admission, weekly thereafter, and upon discharge. During the pre-intervention period, we performed contact precautions based on culture results. In contrast, during the intervention period, we initiated contact precautions within a few hours after sample collection on the basis of LAMP results. Results A total of 1335 patients were admitted to the ICUs, of which 866 patients (pre-intervention period: 187; intervention period: 679) were eligible for this study. Incidence rate of CRAB infection decreased to 20.9 per 1000 patient-days in the intervention period from 35.2 in the pre-intervention period (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2047-2994 |
| Relation: |
http://link.springer.com/article/10.1186/s13756-019-0564-9; https://doaj.org/toc/2047-2994 |
| DOI: |
10.1186/s13756-019-0564-9 |
| Access URL: |
https://doaj.org/article/11a487b66d024487ace74e83bbda6e41 |
| Accession Number: |
edsdoj.11a487b66d024487ace74e83bbda6e41 |
| Database: |
Directory of Open Access Journals |
