Bibliographic Details
| Title: |
Isoform- and cell-state-specific APOE homeostasis and function |
| Authors: |
Karina Lindner, Anne-Claude Gavin |
| Source: |
Neural Regeneration Research, Vol 19, Iss 11, Pp 2456-2466 (2024) |
| Publisher Information: |
Wolters Kluwer Medknow Publications, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neurology. Diseases of the nervous system |
| Subject Terms: |
alzheimer’s disease, apolipoprotein e, autophagy, cholesterol, lipid detoxification, lipid transport, lysosomal failure, metabolic impairment, triacylglycerol, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: |
Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling. It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying them. Apolipoprotein E polymorphism, combined with environmental stresses and/or age-related alterations, influences the risk of developing late-onset Alzheimer’s disease. In this review, we discuss our current knowledge of how apolipoprotein E homeostasis, i.e. its synthesis, secretion, degradation, and lipidation, is affected in Alzheimer’s disease. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1673-5374 |
| Relation: |
http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=11;spage=2456;epage=2466;aulast=Lindner; https://doaj.org/toc/1673-5374 |
| DOI: |
10.4103/NRR.NRR-D-23-01470 |
| Access URL: |
https://doaj.org/article/a11975e73310483f9e9c304cffa30e05 |
| Accession Number: |
edsdoj.11975e73310483f9e9c304cffa30e05 |
| Database: |
Directory of Open Access Journals |
