Bibliographic Details
| Title: |
Amygdalar Functional Connectivity Differences Associated With Reduced Pain Intensity in Pediatric Peripheral Neuropathic Pain |
| Authors: |
Madeleine Verriotis, Clarissa Sorger, Judy Peters, Lizbeth J. Ayoub, Kiran K. Seunarine, Chris A. Clark, Suellen M. Walker, Massieh Moayedi |
| Source: |
Frontiers in Pain Research, Vol 3 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Neurology. Diseases of the nervous system |
| Subject Terms: |
chronic pain, neuropathic pain, functional connectivity, fMRI, limbic, brain, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: |
BackgroundThere is evidence of altered corticolimbic circuitry in adults with chronic pain, but relatively little is known of functional brain mechanisms in adolescents with neuropathic pain (NeuP). Pediatric NeuP is etiologically and phenotypically different from NeuP in adults, highlighting the need for pediatric-focused research. The amygdala is a key limbic region with important roles in the emotional-affective dimension of pain and in pain modulation.ObjectiveTo investigate amygdalar resting state functional connectivity (rsFC) in adolescents with NeuP.MethodsThis cross-sectional observational cohort study compared resting state functional MRI scans in adolescents aged 11–18 years with clinical features of chronic peripheral NeuP (n = 17), recruited from a tertiary clinic, relative to healthy adolescents (n = 17). We performed seed-to-voxel whole-brain rsFC analysis of the bilateral amygdalae. Next, we performed post hoc exploratory correlations with clinical variables to further explain rsFC differences.ResultsAdolescents with NeuP had stronger negative rsFC between right amygdala and right dorsolateral prefrontal cortex (dlPFC) and stronger positive rsFC between right amygdala and left angular gyrus (AG), compared to controls (PFDR |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2673-561X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fpain.2022.918766/full; https://doaj.org/toc/2673-561X |
| DOI: |
10.3389/fpain.2022.918766 |
| Access URL: |
https://doaj.org/article/115006c2ef5f40e298175ceb737f2933 |
| Accession Number: |
edsdoj.115006c2ef5f40e298175ceb737f2933 |
| Database: |
Directory of Open Access Journals |
