Navigating the Link Between Non-alcoholic Fatty Liver Disease/Non-alcoholic Steatohepatitis and Cardiometabolic Syndrome
| Title: | Navigating the Link Between Non-alcoholic Fatty Liver Disease/Non-alcoholic Steatohepatitis and Cardiometabolic Syndrome |
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| Authors: | Sheila Gato, Vanessa García-Fernández, Antonio Gil-Gómez, Ángela Rojas, Rocío Montero-Vallejo, Rocío Muñoz-Hernández, Manuel Romero-Gómez |
| Source: | European Cardiology Review, Vol 19, Iss , Pp - (2024) |
| Publisher Information: | Radcliffe Medical Media, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: | Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: | The global prevalence of non-alcoholic fatty liver disease (NAFLD) is nearly 25% and is increasing rapidly. The spectrum of liver damage in NAFLD ranges from simple steatosis to non-alcoholic steatohepatitis, characterised by the presence of lobular inflammation and hepatocyte ballooning degeneration, with or without fibrosis, which can further develop into cirrhosis and hepatocellular carcinoma. Not only is NAFLD a progressive liver disease, but numerous pieces of evidence also point to extrahepatic consequences. Accumulating evidence suggests that patients with NAFLD are also at increased risk of cardiovascular disease (CVD); in fact, CVDs are the most common cause of mortality in patients with NAFLD. Obesity, type 2 diabetes and higher levels of LDL are common risk factors in both NAFLD and CVD; however, how NAFLD affects the development and progression of CVD remains elusive. In this review, we comprehensively summarise current data on the key extrahepatic manifestations of NAFLD, emphasising the possible link between NAFLD and CVD, including the role of proprotein convertase substilisin/kenin type 9, extracellular vesicles, microbiota, and genetic factors. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1758-3764 1758-3756 |
| Relation: | https://www.ecrjournal.com/articleindex/ecr.2023.26; https://doaj.org/toc/1758-3756; https://doaj.org/toc/1758-3764 |
| DOI: | 10.15420/ecr.2023.26 |
| Access URL: | https://doaj.org/article/a114765cd1dd48c381ccc41cc41f0f8d |
| Accession Number: | edsdoj.114765cd1dd48c381ccc41cc41f0f8d |
| Database: | Directory of Open Access Journals |
| ISSN: | 17583764 17583756 |
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| DOI: | 10.15420/ecr.2023.26 |
| Published in: | European Cardiology Review |
| Language: | English |