Bibliographic Details
| Title: |
Characteristics of a novel photoinitiator aceanthrenequinone-initiated polymerization and cytocompatibility of its triggered polymer |
| Authors: |
Yongjia Xiong, Hailing Zou, Shuhui Wang, Jiawen Guo, Boning Zeng, Pu Xiao, Jing Liu, Feiyue Xing |
| Source: |
Toxicology Reports, Vol 9, Iss , Pp 191-203 (2022) |
| Publisher Information: |
Elsevier, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Toxicology. Poisons |
| Subject Terms: |
Aceanthrenequinone, 9,10-phenanthrenequinone, Photopolymerization, Biocompatibility, Cytotoxicity, Toxicology. Poisons, RA1190-1270 |
| More Details: |
A number of photoinitiators are available in chemical industry, but less of them in biomedicine or clinical therapy due to the limitation of their cytotoxicity and biocompatibility. Thus, it is urgently necessary to find non-toxic or low-toxic photoinitiators to meet clinical demands. Aceanthrenequinone (AATQ) is a novel photosensitizer with high-photoinitiating ability, but no reports contribute, to date, to its cytotoxicity and biocompatibility. Here, primary cells and various cell lines were exposed to different concentrations of AATQ with or without irradiation. AATQ had the similar photoinitiating conversion efficiency to the extensively used bis(2,4,6-trimethylbenzoyl)-phenylphosphine oxide (BAPO) and higher one than 9,10-phenanthrenequinone (PANQ) with the similar extent of polymerization in depth within a certain range, but displayed much lower cytotoxicity than BAPO under non-irradiation or irradiation. The biocompatibility of BisGMA/TEGDMA polymer prepared by AATQ was superior to that of PANQ, but inferior to that of camphorquinone (CQ) although the far lower dose of AATQ is enough to initiate polymerization of monomer than that of CQ. Hence, AATQ offers a valuable alternative in applications of industrial or biomedical areas. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2214-7500 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2214750022000087; https://doaj.org/toc/2214-7500 |
| DOI: |
10.1016/j.toxrep.2022.01.008 |
| Access URL: |
https://doaj.org/article/11397bbe296c432cb8005b93019f927b |
| Accession Number: |
edsdoj.11397bbe296c432cb8005b93019f927b |
| Database: |
Directory of Open Access Journals |
