The systemic and hepatic alternative renin–angiotensin system is activated in liver cirrhosis, linked to endothelial dysfunction and inflammation

Bibliographic Details
Title:	The systemic and hepatic alternative renin–angiotensin system is activated in liver cirrhosis, linked to endothelial dysfunction and inflammation
Authors:	Lukas Hartl, Benedikt Rumpf, Oliver Domenig, Benedikt Simbrunner, Rafael Paternostro, Mathias Jachs, Marko Poglitsch, Rodrig Marculescu, Michael Trauner, Roman Reindl-Schwaighofer, Manfred Hecking, Mattias Mandorfer, Thomas Reiberger
Source:	Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Publisher Information:	Nature Portfolio, 2023.
Publication Year:	2023
Collection:	LCC:Medicine LCC:Science
Subject Terms:	Medicine, Science
More Details:	Abstract We aimed to assess the systemic and hepatic renin-angiotensin-system (RAS) fingerprint in advanced chronic liver disease (ACLD). This prospective study included 13 compensated (cACLD) and 12 decompensated ACLD (dACLD) patients undergoing hepatic venous pressure gradient (HVPG) measurement. Plasma components (all patients) and liver-local enzymes (n = 5) of the RAS were analyzed using liquid chromatography–tandem mass spectrometry. Patients with dACLD had significantly higher angiotensin (Ang) I, Ang II and aldosterone plasma levels. Ang 1–7, a major mediator of the alternative RAS, was almost exclusively detectable in dACLD (n = 12/13; vs. n = 1/13 in cACLD). Also, dACLD patients had higher Ang 1–5 (33.5 pmol/L versus cACLD: 6.6 pmol/L, p
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2045-2322
Relation:	https://doaj.org/toc/2045-2322
DOI:	10.1038/s41598-023-28239-2
Access URL:	https://doaj.org/article/1135ed85629041d8bc558fb1e8dafc54
Accession Number:	edsdoj.1135ed85629041d8bc558fb1e8dafc54
Database:	Directory of Open Access Journals
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More Details
ISSN:	20452322
DOI:	10.1038/s41598-023-28239-2
Published in:	Scientific Reports
Language:	English