Academic Journal
Pediatric acute myeloid leukemia patients with KMT2A rearrangements: a single-center retrospective study
| Title: | Pediatric acute myeloid leukemia patients with KMT2A rearrangements: a single-center retrospective study |
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| Authors: | Wei Yang, Maoquan Qin, Chenguang Jia, Jun Yang, Wei Chen, Yanhui Luo, Yuanfang Jing, Bin Wang |
| Source: | Hematology, Vol 27, Iss 1, Pp 583-589 (2022) |
| Publisher Information: | Taylor & Francis Group, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Diseases of the blood and blood-forming organs |
| Subject Terms: | Acute myeloid leukemia, KMT2A rearrangements, allogeneic hematopoietic stem cell transplantation, children, Diseases of the blood and blood-forming organs, RC633-647.5 |
| More Details: | Purpose Pediatric acute myeloid leukemia (AML) with KMT2A rearrangements has a very different prognosis. Poor outcomes cannot be avoided even after hematopoietic stem cell transplantation. In order to investigate the prognosis and efficacy, we conducted a retrospective analysis.Patients and methods We retrospectively analyzed a total of 32 children with KMT2A rearrangements AML treated in our hospital between January 2015 and February 2021.Results The proportion of patients with KMT2A-rearranged in the medium-risk group of overall survival (OS) and event-free survival (EFS) was 100%. No differences in OS, EFS and cumulative incidence of relapse (CIR) were detected between the haploidentical hematopoietic stem cell transplantation (haplo-HSCT) and full matched HSCT (P = 0.289, P = 0.303, P = 0.303). Acute graft-versus-host disease (aGVHD) was often detected in the haplo-HSCT cohort, while full matched HSCT had no obvious aGVHD, assessed as≤1 grade (P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 16078454 1607-8454 |
| Relation: | https://doaj.org/toc/1607-8454 |
| DOI: | 10.1080/16078454.2022.2071797 |
| Access URL: | https://doaj.org/article/1043c84733904a9086400d58ce3e23fa |
| Accession Number: | edsdoj.1043c84733904a9086400d58ce3e23fa |
| Database: | Directory of Open Access Journals |
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| ISSN: | 16078454 |
|---|---|
| DOI: | 10.1080/16078454.2022.2071797 |
| Published in: | Hematology |
| Language: | English |