Academic Journal
Overall assessment of antibiotic substitutes for pigs: a set of meta-analyses
| Title: | Overall assessment of antibiotic substitutes for pigs: a set of meta-analyses |
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| Authors: | Bocheng Xu, Jie Fu, Luoyi Zhu, Zhi Li, Mingliang Jin, Yizhen Wang |
| Source: | Journal of Animal Science and Biotechnology, Vol 12, Iss 1, Pp 1-15 (2021) |
| Publisher Information: | BMC, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Animal culture LCC:Veterinary medicine |
| Subject Terms: | Antibiotic substitutes, Dose-effect relationship, Feed additives, Meta-analysis, Network meta-analysis, Pigs, Animal culture, SF1-1100, Veterinary medicine, SF600-1100 |
| More Details: | Abstract Background Antibiotic growth promoters are widely used to improve weight gain. However, the abuse of antibiotics can have many negative effects on people. Developing alternatives to antibiotics is an urgent need in livestock production. We aimed to perform a meta-analysis and network meta-analysis (NMA) to investigate the effects of feed additives as potential antibiotic substitutes (ASs) on bacteriostasis, growth performance, intestinal morphology and immunity. Furthermore, the primary, secondary, and tertiary ASs were defined by comparing their results with the results of antibiotics. Results Among 16,309 identified studies, 37 were summarized to study the bacteriostasis effects of feed additives, and 89 were included in the meta-analysis and NMA (10,228 pigs). We summarized 268 associations of 57 interventions with 32 bacteria. The order of bacteriostasis effects was as follows: antimicrobial peptides (AMPs) ≈ antibiotics>organic acids>plant extracts>oligosaccharides. We detected associations of 11 feed additives and 11 outcomes. Compared with a basal diet, plant extract, AMPs, probiotics, microelements, organic acids, bacteriophages, lysozyme, zymin, and oligosaccharides significantly improved growth performance (P 0.05); AMPs and microelements significantly increased V/C (P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2049-1891 |
| Relation: | https://doaj.org/toc/2049-1891 |
| DOI: | 10.1186/s40104-020-00534-2 |
| Access URL: | https://doaj.org/article/102b1828bf50499fb1e82cf1447f22c8 |
| Accession Number: | edsdoj.102b1828bf50499fb1e82cf1447f22c8 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20491891 |
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| DOI: | 10.1186/s40104-020-00534-2 |
| Published in: | Journal of Animal Science and Biotechnology |
| Language: | English |