Academic Journal
Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy
| Title: | Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy |
|---|---|
| Authors: | Claudia Soledad Sepúlveda, Cybele Carina García, Elsa Beatriz Damonte |
| Source: | Microorganisms, Vol 10, Iss 8, p 1631 (2022) |
| Publisher Information: | MDPI AG, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Biology (General) |
| Subject Terms: | wide-spectrum antiviral, host-targeted antiviral, nucleotide metabolism, de novo biosynthesis pathway, salvage pathway, pyrimidines, Biology (General), QH301-705.5 |
| More Details: | Emerging and re-emerging viruses have been a challenge in public health in recent decades. Host-targeted antivirals (HTA) directed at cellular molecules or pathways involved in virus multiplication represent an interesting strategy to combat viruses presently lacking effective chemotherapy. HTA could provide a wide range of agents with inhibitory activity against current and future viruses that share similar host requirements and reduce the possible selection of antiviral-resistant variants. Nucleotide metabolism is one of the more exploited host metabolic pathways as a potential antiviral target for several human viruses. This review focuses on the antiviral properties of the inhibitors of pyrimidine and purine nucleotide biosynthesis, with an emphasis on the rate-limiting enzymes dihydroorotate dehydrogenase (DHODH) and inosine monophosphate dehydrogenase (IMPDH) for which there are old and new drugs active against a broad spectrum of pathogenic viruses. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 10081631 2076-2607 |
| Relation: | https://www.mdpi.com/2076-2607/10/8/1631; https://doaj.org/toc/2076-2607 |
| DOI: | 10.3390/microorganisms10081631 |
| Access URL: | https://doaj.org/article/102aa6419fad4a04aacbf1c2f15afaa5 |
| Accession Number: | edsdoj.102aa6419fad4a04aacbf1c2f15afaa5 |
| Database: | Directory of Open Access Journals |
| ISSN: | 10081631 20762607 |
|---|---|
| DOI: | 10.3390/microorganisms10081631 |
| Published in: | Microorganisms |
| Language: | English |