Bibliographic Details
| Title: |
Intestinal Microbiota - An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury |
| Authors: |
Zhengjian Wang, Fan Li, Jin Liu, Yalan Luo, Haoya Guo, Qi Yang, Caiming Xu, Shurong Ma, Hailong Chen |
| Source: |
Frontiers in Immunology, Vol 13 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
severe acute pancreatitis-associated lung injury, intestinal microbiota, microbiota-gut-lung axis, bacterial translocation, pathogen-associated molecular patterns, immune imbalance, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Severe acute pancreatitis (SAP), one of the most serious abdominal emergencies in general surgery, is characterized by acute and rapid onset as well as high mortality, which often leads to multiple organ failure (MOF). Acute lung injury (ALI), the earliest accompanied organ dysfunction, is the most common cause of death in patients following the SAP onset. The exact pathogenesis of ALI during SAP, however, remains unclear. In recent years, advances in the microbiota-gut-lung axis have led to a better understanding of SAP-associated lung injury (PALI). In addition, the bidirectional communications between intestinal microbes and the lung are becoming more apparent. This paper aims to review the mechanisms of an imbalanced intestinal microbiota contributing to the development of PALI, which is mediated by the disruption of physical, chemical, and immune barriers in the intestine, promotes bacterial translocation, and results in the activation of abnormal immune responses in severe pancreatitis. The pathogen-associated molecular patterns (PAMPs) mediated immunol mechanisms in the occurrence of PALI via binding with pattern recognition receptors (PRRs) through the microbiota-gut-lung axis are focused in this study. Moreover, the potential therapeutic strategies for alleviating PALI by regulating the composition or the function of the intestinal microbiota are discussed in this review. The aim of this study is to provide new ideas and therapeutic tools for PALI patients. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2022.913178/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2022.913178 |
| Access URL: |
https://doaj.org/article/eae0feaeb6fb42b08a2e1403a02dbfe7 |
| Accession Number: |
edsdoj.0feaeb6fb42b08a2e1403a02dbfe7 |
| Database: |
Directory of Open Access Journals |
