Academic Journal
Impact of an oligosaccharide-based polymer on the metabolic profiles and microbial ecology of weanling pigs experimentally infected with a pathogenic E. coli
| Title: | Impact of an oligosaccharide-based polymer on the metabolic profiles and microbial ecology of weanling pigs experimentally infected with a pathogenic E. coli |
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| Authors: | Kwangwook Kim, Cynthia Jinno, Xunde Li, David Bravo, Eric Cox, Peng Ji, Yanhong Liu |
| Source: | Journal of Animal Science and Biotechnology, Vol 15, Iss 1, Pp 1-16 (2024) |
| Publisher Information: | BMC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Animal culture LCC:Veterinary medicine |
| Subject Terms: | Carbadox, Colon microbiota, Enterotoxigenic E. coli F18, Metabolomics, Oligosaccharide-based polymer, Weaned pigs, Animal culture, SF1-1100, Veterinary medicine, SF600-1100 |
| More Details: | Abstract Background Our previous study has reported that supplementation of oligosaccharide-based polymer enhances gut health and disease resistance of pigs infected with enterotoxigenic E. coli (ETEC) F18 in a manner similar to carbadox. The objective of this study was to investigate the impacts of oligosaccharide-based polymer or antibiotic on the host metabolic profiles and colon microbiota of weaned pigs experimentally infected with ETEC F18. Results Multivariate analysis highlighted the differences in the metabolic profiles of serum and colon digesta which were predominantly found between pigs supplemented with oligosaccharide-based polymer and antibiotic. The relative abundance of metabolic markers of immune responses and nutrient metabolisms, such as amino acids and carbohydrates, were significantly differentiated between the oligosaccharide-based polymer and antibiotic groups (q 2.0). In addition, pigs in antibiotic had a reduced (P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2049-1891 |
| Relation: | https://doaj.org/toc/2049-1891 |
| DOI: | 10.1186/s40104-023-00956-8 |
| Access URL: | https://doaj.org/article/0f762a5d311f40feb3a19e16a05e55d0 |
| Accession Number: | edsdoj.0f762a5d311f40feb3a19e16a05e55d0 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20491891 |
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| DOI: | 10.1186/s40104-023-00956-8 |
| Published in: | Journal of Animal Science and Biotechnology |
| Language: | English |