Academic Journal
Degradable carrier-free spray hydrogel based on self-assembly of natural small molecule for prevention of postoperative adhesion
| Title: | Degradable carrier-free spray hydrogel based on self-assembly of natural small molecule for prevention of postoperative adhesion |
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| Authors: | Linjun Zou, Yong Hou, Jiawen Zhang, Meiying Chen, Peiying Wu, Changcun Feng, Qinglong Li, Xudong Xu, Zhaocui Sun, Guoxu Ma |
| Source: | Materials Today Bio, Vol 22, Iss , Pp 100755- (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine (General) LCC:Biology (General) |
| Subject Terms: | Natural spray hydrogel, Postoperative peritoneal adhesion, Glycyrrhetinic acid, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| More Details: | Postoperative peritoneal adhesion (PPA) is frequent and extremely dangerous complication after surgery. Different tactics have been developed to reduce it. However, creating a postoperative adhesion method that is multifunctional, biodegradable, biocompatible, low-toxic but highly effective, and therapeutically applicable is still a challenge. Herein, we have prepared a degradable spray glycyrrhetinic acid hydrogel (GAG) based on natural glycyrrhetinic acid (GA) by straightforward heating and cooling without the use of any additional chemical cross-linking agents to prevent postoperative adhesion. The resultant hydrogel was demonstrated to possess various superior anti-inflammatory activity, and multiple functions, such as excellent degradability and biocompatibility. Specifically, spraying characteristic and excellent antibacterial activities essentially eliminated secondary infections during the administration of drugs in surgical wounds. In the rat models, the carrier-free spray GAG could not only slow-release GA to inhibit inflammatory response, but also serve as physical anti-adhesion barrier to reduce collagen deposition and fibrosis. The sprayed GAG would shed a new light on the prevention of postoperative adhesion and broaden the application of the hydrogels based on natural products in biomedical fields. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2590-0064 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2590006423002156; https://doaj.org/toc/2590-0064 |
| DOI: | 10.1016/j.mtbio.2023.100755 |
| Access URL: | https://doaj.org/article/0f41d189790a4ea69ada3cf4883d6158 |
| Accession Number: | edsdoj.0f41d189790a4ea69ada3cf4883d6158 |
| Database: | Directory of Open Access Journals |
| ISSN: | 25900064 |
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| DOI: | 10.1016/j.mtbio.2023.100755 |
| Published in: | Materials Today Bio |
| Language: | English |