Academic Journal
Brain temperature as an indicator of neuroinflammation induced by typhoid vaccine: Assessment using whole-brain magnetic resonance spectroscopy in a randomised crossover study
| Title: | Brain temperature as an indicator of neuroinflammation induced by typhoid vaccine: Assessment using whole-brain magnetic resonance spectroscopy in a randomised crossover study |
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| Authors: | Julia R. Plank, Catherine Morgan, Frederick Sundram, Lindsay D. Plank, Nicholas Hoeh, Sinyeob Ahn, Suresh Muthukumaraswamy, Joanne C. Lin |
| Source: | NeuroImage: Clinical, Vol 35, Iss , Pp 103053- (2022) |
| Publisher Information: | Elsevier, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Computer applications to medicine. Medical informatics LCC:Neurology. Diseases of the nervous system |
| Subject Terms: | Neuroinflammation, Brain temperature, Magnetic resonance spectroscopy, Echo-planar spectroscopic imaging, Metabolites, Mood, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: | Prior studies indicate a pathogenic role of neuroinflammation in psychiatric disorders; however, there are no accepted methods that can reliably measure low-level neuroinflammation non-invasively in these individuals. Magnetic resonance spectroscopic imaging (MRSI) is a versatile, non-invasive neuroimaging technique that demonstrates sensitivity to brain inflammation. MRSI in conjunction with echo-planar spectroscopic imaging (EPSI) measures brain metabolites to derive whole-brain and regional brain temperatures, which may increase in neuroinflammation. The validity of MRSI/EPSI for measurement of low level neuroinflammation was tested using a safe experimental model of human brain inflammation – intramuscular administration of typhoid vaccine. Twenty healthy volunteers participated in a double-blind, placebo-controlled crossover study including MRSI/EPSI scans before and 3 h after vaccine/placebo administration. Body temperature and mood, assessed using the Profile of Mood States, were measured every hour up to four hours post-treatment administration. A mixed model analysis of variance was used to test for treatment effects. A significant proportion of brain regions (44/47) increased in temperature post-vaccine compared to post-placebo (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2213-1582 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213158222001188; https://doaj.org/toc/2213-1582 |
| DOI: | 10.1016/j.nicl.2022.103053 |
| Access URL: | https://doaj.org/article/d0eae755bb394a619250b450bde5f141 |
| Accession Number: | edsdoj.0eae755bb394a619250b450bde5f141 |
| Database: | Directory of Open Access Journals |
| ISSN: | 22131582 |
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| DOI: | 10.1016/j.nicl.2022.103053 |
| Published in: | NeuroImage: Clinical |
| Language: | English |