| Title: |
USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer |
| Authors: |
Dongni Shi, Xianqiu Wu, Yunting Jian, Junye Wang, Chengmei Huang, Shuang Mo, Yue Li, Fengtian Li, Chao Zhang, Dongsheng Zhang, Huizhong Zhang, Huilin Huang, Xin Chen, Y. Alan Wang, Chuyong Lin, Guozhen Liu, Libing Song, Wenting Liao |
| Source: |
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022) |
| Publisher Information: |
Nature Portfolio, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
IDO1-mediated tryptophan metabolism plays an important role in creating an immunosuppressive tumour microenvironment. Here, the authors show that deubiquitinase USP14 regulates immune suppression by inducing IDO1 stabilization and suggest USP14 as a potential therapeutic target to improve immunotherapy in colorectal cancer. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-022-33285-x |
| Access URL: |
https://doaj.org/article/da0e7849fcb34a24976064852f9e4e8c |
| Accession Number: |
edsdoj.0e7849fcb34a24976064852f9e4e8c |
| Database: |
Directory of Open Access Journals |
