Monitoring and immunogenicity of SARS-CoV-2 vaccination of laboratory rhesus monkeys (Macaca mulatta)

Bibliographic Details
Title: Monitoring and immunogenicity of SARS-CoV-2 vaccination of laboratory rhesus monkeys (Macaca mulatta)
Authors: Dan Qi Priscilla Oh, Iris Grothe, Herbert Lukaß, Andreas K. Kreiter, Markus Hoffmann, Detlef Wegener
Source: Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Publisher Information: Nature Portfolio, 2023.
Publication Year: 2023
Collection: LCC:Medicine
LCC:Science
Subject Terms: Medicine, Science
More Details: Abstract The availability of effective vaccines and a high vaccination rate allowed the recent mitigation, or even withdrawal, of many protective measures for containing the SARS CoV-2 pandemic. At the same time, new and highly mutated variants of the virus are found to have significantly higher transmissibility and reduced vaccine efficacy, thus causing high infection rates during the third year of the pandemic. The combination of reduced measures and increased infectivity poses a particular risk for unvaccinated individuals, including animals susceptible to the virus. Among the latter, non-human primates (NHPs) are particularly vulnerable. They serve as important models in various fields of biomedical research and because of their cognitive capabilities, they receive particular attention in animal welfare regulations around the world. Yet, although they played an extraordinarily important role for developing and testing vaccines against SARS-CoV-2, the protection of captive rhesus monkeys against Covid-19 has rarely been discussed. We here report upon twofold mRNA vaccination of a cohort of 19 elderly rhesus monkeys (Macaca mulatta) against infection by SARS-CoV-2. All animals were closely monitored on possible side effects of vaccination, and were tested for neutralising antibodies against the virus. The data show that vaccination of rhesus monkeys is a safe and reliable measure to protect these animals against SARS-CoV-2.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-023-30473-7
Access URL: https://doaj.org/article/0e2fb198b56a449f8bf5d9cf81198e71
Accession Number: edsdoj.0e2fb198b56a449f8bf5d9cf81198e71
Database: Directory of Open Access Journals
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More Details
ISSN:20452322
DOI:10.1038/s41598-023-30473-7
Published in:Scientific Reports
Language:English