Academic Journal
The effect of taurolidine on the time-to-positivity of blood cultures
| Title: | The effect of taurolidine on the time-to-positivity of blood cultures |
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| Authors: | C.H. van den Bosch, J.E.P. Moree, S. Peeters, M. Lankheet, A.F.W. van der Steeg, M.H.W.A. Wijnen, M.D. van de Wetering, J.T. van der Bruggen |
| Source: | Infection Prevention in Practice, Vol 6, Iss 2, Pp 100352- (2024) |
| Publisher Information: | Elsevier, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Infectious and parasitic diseases LCC:Public aspects of medicine |
| Subject Terms: | Central line-associated bloodstream infection, Taurolidine, Taurolock, Paediatric oncology, Central venous access, Blood culture, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270 |
| More Details: | Summary: Background: Taurolidine containing lock solutions (TL) are a promising method for the prevention of central line associated bloodstream infections. Per accident, the TL may not always be aspirated from the central venous catheter (CVC) before blood cultures are obtained. The TL could, unintentionally, end up in a blood culture vial, possibly altering the results. The aim of this study was to investigate the effect of the TLs on the detection of microbial growth in blood culture vials. Methods: Different lock solutions (taurolidine-citrate-heparin (TCHL), taurolidine, heparin, citrate or NaCl) were added to BD BACTECTM blood culture vials (Plus Aerobic/F, Lytic/10 Anaerobic/F or Peds Plus/F) before spiking with Staphylococcus aureus (ATCC 29213 or a clinical strain) or Escherichia coli (ATCC 25922 or a clinical strain) in the presence and absence of blood. Subsequently, blood culture vials were incubated in the BD BACTEC FX instrument with Time-to-positivity (TTP) as primary outcome. In addition, the effect of the TCHL on a variety of other micro-organisms was tested. Discussion: In the presence of taurolidine, the TTP was considerably delayed or vials even remained negative as compared to vials containing heparin, citrate or NaCl. This effect was dose-dependent. The delayed TTP was much less pronounced in the presence of blood, but still notable. Conclusion: This study stresses the clinical importance of discarding TLs from the CVC before obtaining a blood culture. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2590-0889 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2590088924000167; https://doaj.org/toc/2590-0889 |
| DOI: | 10.1016/j.infpip.2024.100352 |
| Access URL: | https://doaj.org/article/d0df915dc13c49f2bafccc31c3390e86 |
| Accession Number: | edsdoj.0df915dc13c49f2bafccc31c3390e86 |
| Database: | Directory of Open Access Journals |
| ISSN: | 25900889 |
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| DOI: | 10.1016/j.infpip.2024.100352 |
| Published in: | Infection Prevention in Practice |
| Language: | English |