Academic Journal
In vivo monitoring of the therapeutic efficacy of a CXCR1/2 inhibitor with 18F-FDG PET/CT imaging in experimental head and neck carcinoma: A feasibility study
| Title: | In vivo monitoring of the therapeutic efficacy of a CXCR1/2 inhibitor with 18F-FDG PET/CT imaging in experimental head and neck carcinoma: A feasibility study |
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| Authors: | Christopher Montemagno, Benjamin Serrano, Jérôme Durivault, Valérie Nataf, François Mocquot, Régis Amblard, Valérie Vial, Cyril Ronco, Rachid Benhida, Maeva Dufies, Marc Faraggi, Gilles Pagès |
| Source: | Biochemistry and Biophysics Reports, Vol 27, Iss , Pp 101098- (2021) |
| Publisher Information: | Elsevier, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Biology (General) LCC:Biochemistry |
| Subject Terms: | CXCR1/2, HNSCCs, Chemical inhibitor, 18F-FDG, PET/CT imaging, Biology (General), QH301-705.5, Biochemistry, QD415-436 |
| More Details: | The chemokine receptors CXCR1/2 play a key role in the aggressiveness of several types of cancers including head and neck squamous cell carcinomas (HNSCCs). In HNSCCs, CXCR1/2 signaling promotes cell proliferation and angiogenesis leading to tumor growth and metastasis. The competitive inhibitor of CXCR1/2, C29, inhibits the growth of experimental HNSCCs in mice. However, a non-invasive tool to monitor treatment response is essential to implement the use of C29 in clinical practices. 18F-FDG PET/CT is a gold-standard tool for the staging and the post-therapy follow-up of HNSCCs patients. Our study aimed to perform the first in vivo monitoring of C29 efficacy by non-invasive 18F-FDG PET/CT imaging. Mice bearing experimental HNSCCs (CAL33) were injected with 18F-FDG (T0) and thereafter treated (n = 7 mice, 9 tumors, 50 mg/kg by gavage) or not (n = 7 mice, 10 tumors) with C29 for 4 consecutive days. Final 18F-FDG-tumor uptake was determined at day 4 (TF). The average relative change (TF-T0) in 18F-FDG tumor uptake was +25.85 ± 10.93 % in the control group vs −5.72 ± 10.07 % in the C29-treated group (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-5808 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S240558082100193X; https://doaj.org/toc/2405-5808 |
| DOI: | 10.1016/j.bbrep.2021.101098 |
| Access URL: | https://doaj.org/article/0de8f2a07b134e0aa3203e7045cbdfa2 |
| Accession Number: | edsdoj.0de8f2a07b134e0aa3203e7045cbdfa2 |
| Database: | Directory of Open Access Journals |
| ISSN: | 24055808 |
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| DOI: | 10.1016/j.bbrep.2021.101098 |
| Published in: | Biochemistry and Biophysics Reports |
| Language: | English |