Academic Journal
Impact of using cross-over CV and mean for two different lots of assay control on implementation of Westgard rules in chemical diagnostic tests
| Title: | Impact of using cross-over CV and mean for two different lots of assay control on implementation of Westgard rules in chemical diagnostic tests |
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| Authors: | Ayman Mohamed Nabil, Hayat Mirza Alsaif, Muneer Ahmad Aljamaan, Abdullah Abdullah H. Algafly, Rashad Hassan aleid, Raji Ali Helal, Zainab Ali Hussain almutawah, Amani Abdulkareem S. Alzayer, Walaa Ali Hussain Almutawah, Badr Abdullah Motlaq AlKhalaf |
| Source: | Practical Laboratory Medicine, Vol 44, Iss , Pp e00449- (2025) |
| Publisher Information: | Elsevier, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Medicine (General) LCC:Chemistry |
| Subject Terms: | Quality control, Westgard rule, Cross-over coefficient, Accuracy, Diagnostic test reliability, Reagent lot variation, Medicine (General), R5-920, Chemistry, QD1-999 |
| More Details: | Background: The main challenges of clinical laboratories concerning quality control include cost-effectiveness, variability in standardized materials, and evolving technologies across various diagnostic fields. While traditional QC practices and automation systems provide for accuracy, gaps exist, especially when applying Westgard rules to control lots for multiple assays. Such gaps result in inconsistent QC outcomes and unaddressed challenges in diagnostic reliability. Objective: This study aims to assess the effect of the cross-over coefficient of variation (CV) and mean values for different assay control lots on implementing Westgard rules to improve QC practices and enhance the accuracy and reliability of diagnostic tests in molecular laboratories. Methods: Data from 18 Levy-Jennings charts, with two assay control lots, were analyzed. Statistical comparisons of failure rates before and after setting the actual SD were performed using chi-square or T-tests at p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2352-5517 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352551725000022; https://doaj.org/toc/2352-5517 |
| DOI: | 10.1016/j.plabm.2025.e00449 |
| Access URL: | https://doaj.org/article/a0d8b88f17bd46dfab385fc2bd3cee61 |
| Accession Number: | edsdoj.0d8b88f17bd46dfab385fc2bd3cee61 |
| Database: | Directory of Open Access Journals |
| ISSN: | 23525517 |
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| DOI: | 10.1016/j.plabm.2025.e00449 |
| Published in: | Practical Laboratory Medicine |
| Language: | English |