Expression pattern of long non-coding RNAs in treatment-naïve and medicated schizophrenia patients

Bibliographic Details
Title:	Expression pattern of long non-coding RNAs in treatment-naïve and medicated schizophrenia patients
Authors:	Kamran Javidi Aghdam, Behzad Baradaran, Shima Rahmani, Fatemeh Manafzadeh, Seyed Gholamreza Noor Azar, Shahrokh Aghayan, Asghar Shayannia, Soudeh Ghafouri-Fard
Source:	Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Publisher Information:	Nature Portfolio, 2024.
Publication Year:	2024
Collection:	LCC:Medicine LCC:Science
Subject Terms:	Schizophrenia, IFNG, IL18R, IL18RAP, IFNG-AS1-001, Medicine, Science
More Details:	Abstract Schizophrenia is a disabling mental disorder that affects 1% of people over their lifetime. The etiology and mechanism of schizophrenia are very complex, and many genes are involved in many different signaling pathways in the etiology of this disease. According to recent studies, one of the important mechanisms altered in this disorder is the regulation of immune system and the inflammation mechanism. In the present study, we evaluated the peripheral blood expression pattern of four lncRNAs and three protein-coding genes in the treatment- naïve patients, and medicated patients compared with sex and age-matched controls. In the medicated-patients, expression levels of IFNG, IL18RAP, AC007278.2 were significantly up-regulated (P
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2045-2322
Relation:	https://doaj.org/toc/2045-2322
DOI:	10.1038/s41598-024-78220-w
Access URL:	https://doaj.org/article/0d60b5a361f14fa8b01c77e03a5880dd
Accession Number:	edsdoj.0d60b5a361f14fa8b01c77e03a5880dd
Database:	Directory of Open Access Journals
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More Details
ISSN:	20452322
DOI:	10.1038/s41598-024-78220-w
Published in:	Scientific Reports
Language:	English