NLRP3 Inflammasome: Activation and Regulation in Age-Related Macular Degeneration
| Title: | NLRP3 Inflammasome: Activation and Regulation in Age-Related Macular Degeneration |
|---|---|
| Authors: | Jiangyuan Gao, Ruozhou Tom Liu, Sijia Cao, Jing Z. Cui, Aikun Wang, Eleanor To, Joanne A. Matsubara |
| Source: | Mediators of Inflammation, Vol 2015 (2015) |
| Publisher Information: | Hindawi Limited, 2015. |
| Publication Year: | 2015 |
| Collection: | LCC:Pathology |
| Subject Terms: | Pathology, RB1-214 |
| More Details: | Age-related macular degeneration (AMD) is the leading cause of legal blindness in the elderly in industrialized countries. AMD is a multifactorial disease influenced by both genetic and environmental risk factors. Progression of AMD is characterized by an increase in the number and size of drusen, extracellular deposits, which accumulate between the retinal pigment epithelium (RPE) and Bruch’s membrane (BM) in outer retina. The major pathways associated with its pathogenesis include oxidative stress and inflammation in the early stages of AMD. Little is known about the interactions among these mechanisms that drive the transition from early to late stages of AMD, such as geographic atrophy (GA) or choroidal neovascularization (CNV). As part of the innate immune system, inflammasome activation has been identified in RPE cells and proposed to be a causal factor for RPE dysfunction and degeneration. Here, we will first review the classic model of inflammasome activation, then discuss the potentials of AMD-related factors to activate the inflammasome in both nonocular immune cells and RPE cells, and finally introduce several novel mechanisms for regulating the inflammasome activity. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0962-9351 1466-1861 |
| Relation: | https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861 |
| DOI: | 10.1155/2015/690243 |
| Access URL: | https://doaj.org/article/0d2d3063c364495e8f69ca9beeda1bf5 |
| Accession Number: | edsdoj.0d2d3063c364495e8f69ca9beeda1bf5 |
| Database: | Directory of Open Access Journals |
| ISSN: | 09629351 14661861 |
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| DOI: | 10.1155/2015/690243 |
| Published in: | Mediators of Inflammation |
| Language: | English |