Bibliographic Details
| Title: |
Cannabidiol improves memory and decreases IL-1β serum levels in rats with lipopolysaccharide-induced inflammation |
| Authors: |
Maria Georgieva-Kotetarova, Ilin Kandilarov, Natalia Vilmosh, Hristina Zlatanova, Nikolay Yanchev, Delian Delev, Tihomir Dermendzhiev, Marianna Murdjeva, Ivanka Kostadinova, Ilia Kostadinov |
| Source: |
Folia Medica, Vol 65, Iss 6, Pp 940-949 (2023) |
| Publisher Information: |
Pensoft Publishers, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
Medicine |
| More Details: |
Aim: Memory improving and anti-inflammatory properties of cannabidiol (CBD) were investigated in an experimental model of lipopolysaccharide (LPS)-induced inflammation. Materials and methods: Male Wistar rats were randomly divided into 4 groups: control, LPS control, LPS + CBD 5 mg/kg bw, and LPS + CBD 10 mg/kg bw. Animals were treated with CBD 14 days before LPS administration and throughout the experiment. Step-through passive avoidance task, Y-maze, and novel object recognition test (NORT) were used to assess the memory functions. The following parameters were recorded: latency time, spontaneous alternations percentage (SA%) and recognition index (RI). IL-10, IL-6, TNF-α, and IL-1β serum levels were measured to evaluate the immunomodulatory properties of CBD. Results: LPS led to significant decrease of the recorded parameters in all memory tasks. This demonstrated the memory-impairing effect of LPS-induced inflammation. In the Y-maze and NORT tests, both doses of CBD increased SA% and RI, respectively. Significant difference was found in comparison with the LPS controls. Rats from the CBD treated groups showed increased latency in the step-through passive avoidance task. In the short-term memory test, both CBD doses significantly increased this parameter when compared with both control groups (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1314-2143 |
| Relation: |
https://foliamedica.bg/article/107259/download/pdf/; https://foliamedica.bg/article/107259/download/xml/; https://foliamedica.bg/article/107259/; https://doaj.org/toc/1314-2143 |
| DOI: |
10.3897/folmed.65.e107259 |
| Access URL: |
https://doaj.org/article/d0cd18d8a3ee471f9c1c4b03cc94f2ed |
| Accession Number: |
edsdoj.0cd18d8a3ee471f9c1c4b03cc94f2ed |
| Database: |
Directory of Open Access Journals |
